Glucagon-like Peptide 1 Conjugated to Recombinant Human Serum Albumin Variants with Modified Neonatal Fc Receptor Binding Properties. Impact on Molecular Structure and Half-Life

• Published in: Biochemistry (Easton) Vol. 56; no. 36; pp. 4860 - 4870
• Main Authors: Bukrinski, Jens T, Sønderby, Pernille, Antunes, Filipa, Andersen, Birgitte, Schmidt, Esben G. W, Peters, Günther H. J, Harris, Pernille
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.09.2017
• Subjects: Animals; Binding, Competitive; Female; Glucagon-Like Peptide 1 - chemistry; Half-Life; Histocompatibility Antigens Class I - chemistry; Humans; Mice; Protein Binding; Protein Conformation; Protein Stability; Receptors, Fc - chemistry; Recombinant Fusion Proteins - chemistry; Recombinant Fusion Proteins - pharmacokinetics; Serum Albumin - chemistry

Glucagon-like peptide 1 (GLP-1) is a small incretin hormone stimulated by food intake, resulting in an amplification of the insulin response. Though GLP-1 is interesting as a drug candidate for the treatment of type 2 diabetes mellitus, its short plasma half-life of <3 min limits its clinical use...