Features and Functional Importance of Key Residues of the Mycobacterium tuberculosis Cytochrome bd Oxidase

• Published in: ACS infectious diseases Vol. 6; no. 7; pp. 1697 - 1707
• Main Authors: Sviriaeva, Ekaterina, Subramanian Manimekalai, Malathy Sony, Grüber, Gerhard, Pethe, Kevin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 10.07.2020
• Subjects: respiration; proton transfer; bioenergetics; Mycobacterium tuberculosis; oxygen; cytochrome oxidases

Cytochrome bd (cyt-bd) oxygen reductases have a high affinity to oxygen and use the two electrons provided by ubiquinol or menaquinol, like in mycobacteria, to reduce oxygen to water. Although they do not pump protons from the cytoplasmic to the periplasmic side, they generate a proton motive force...