Recrystallization of Adenosine for Localized Drug Delivery

• Published in: Molecular pharmaceutics Vol. 19; no. 9; pp. 3394 - 3404
• Main Authors: Velankar, Ketki Y., Mou, Mingyao, Hartmeier, Paul R., Clegg, Benjamin, Gawalt, Ellen S., Jiang, Mo, Meng, Wilson S.
• Format: Journal Article
• Language: English
• Published: American Chemical Society 05.09.2022
• Subjects: immunomodulation; drug delivery; inflammation; highly concentrated formulations; albumin; pharmaceutical crystals

Adenosine (ADO) is an endogenous metabolite with immense potential to be repurposed as an immunomodulatory therapeutic, as preclinical studies have demonstrated in models of epilepsy, acute respiratory distress syndrome, and traumatic brain injury, among others. The currently licensed products Adeno...