Chiral Lewis Acid-Catalyzed Asymmetric Multicomponent Michael Reaction through [1,2]-Phospha-Brook Rearrangement

• Published in: Organic letters Vol. 25; no. 34; pp. 6262 - 6266
• Main Authors: Lin, Qianchi, Wang, Siyuan, Weng, Rui, Cao, Weidi, Feng, Xiaoming
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.09.2023; Amer Chemical Soc
• Subjects: catalysts; chemical reactions; Chemistry; Chemistry, Organic; Lewis acids; Physical Sciences; Science & Technology; CHEMISTRY; CYCLOADDITION; ALPHA-KETOESTERS; LIGANDS; ISATINS

The multicomponent catalytic asymmetric Pudovik addition/[1,2]-phospha-Brook rearrangement/Michael reaction sequence of isatins, phosphites, and 4-oxobutenoates was realized. A series of oxindole derivatives containing two contiguous stereocenters was obtained in high yields and excellent stereosele...