Environment-Friendly Bromination of Aromatic Heterocycles Using a Bromide–Bromate Couple in an Aqueous Medium

• Published in: Industrial & engineering chemistry research Vol. 50; no. 21; pp. 12271 - 12275
• Main Authors: Joshi, Girdhar, Adimurthy, Subbarayappa
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 02.11.2011
• Subjects: Activation; Applied sciences; Aromatic compounds; Bromates; Bromides; Bromination; Chemical engineering; Exact sciences and technology; Heterocyclic compounds; Industrial engineering; Joining; Bromination; Aqueous medium

Selective monobromination of aromatic heterocyclic compounds through in-situ acid activation of 2:1 bromide/bromate couple as a benign brominating reagent is described. The in-situ acid activation of a bromide–bromate couple generates the reactive species BrOH, and it is proved to be an efficient fo...