Environment-Friendly Bromination of Aromatic Heterocycles Using a Bromide–Bromate Couple in an Aqueous Medium

Selective monobromination of aromatic heterocyclic compounds through in-situ acid activation of 2:1 bromide/bromate couple as a benign brominating reagent is described. The in-situ acid activation of a bromide–bromate couple generates the reactive species BrOH, and it is proved to be an efficient fo...

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Bibliographic Details
Published inIndustrial & engineering chemistry research Vol. 50; no. 21; pp. 12271 - 12275
Main Authors Joshi, Girdhar, Adimurthy, Subbarayappa
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 02.11.2011
Subjects
Activation
Applied sciences
Aromatic compounds
Bromates
Bromides
Bromination
Chemical engineering
Exact sciences and technology
Heterocyclic compounds
Industrial engineering
Joining
Bromination
Aqueous medium
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Summary:Selective monobromination of aromatic heterocyclic compounds through in-situ acid activation of 2:1 bromide/bromate couple as a benign brominating reagent is described. The in-situ acid activation of a bromide–bromate couple generates the reactive species BrOH, and it is proved to be an efficient for the bromination of various heterocycles under mild aqueous conditions without the use of any catalyst. Heterocycles that had electron-rich substituents provided good yields.
Bibliography:ObjectType-Article-1
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ISSN:0888-5885
1520-5045
DOI:10.1021/ie2004863