Photo-Triggered Release of Caged Camptothecin Prodrugs from Dually Responsive Shell Cross-Linked Micelles

• Published in: Macromolecules Vol. 46; no. 15; pp. 6243 - 6256
• Main Authors: Hu, Xianglong, Tian, Jie, Liu, Tao, Zhang, Guoying, Liu, Shiyong
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 13.08.2013
• Subjects: aniline; Applied sciences; benzaldehyde; Biological and medical sciences; bromine; catalytic activity; cell viability; chemical bonding; chlorine; composite polymers; copolymerization; crosslinking; cytosol; cytotoxicity; drug therapy; drugs; Exact sciences and technology; folate receptors; folic acid; General pharmacology; hydrophilicity; hydrophobicity; irradiation; ligands; Medical sciences; micelles; moieties; nanocarriers; neoplasm cells; neoplasms; Organic polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; thiols; viability assays; Antineoplastic agent; Ring opening polymerization; 1,3-Dipolar cycloaddition; Hydrodynamic radius; Triazole derivative copolymer; Graft copolymer; Atom transfer polymerization; Propargylic compound; Mixed micelle; Drug carrier; Macromer; Ethylene oxide polymer; Caprolactone copolymer; Release; Amphiphilic polymer; Camptothecin derivatives; Control release polymer; Crosslinking; Prodrug; Ethylene oxide copolymer; Dimension spectrum; Chemical modification; Preparation; Diblock copolymer; Light sensitive copolymer; Methacrylate copolymer; Aqueous solution; Micellar solution; Ring opening copolymerization

We report on the fabrication of dynamic covalent shell cross-linked (SCL) micelles with hydrophobic cores conjugated with photocaged chemotherapeutic drugs and coronas functionalized with ligands for tumor cell targeting. Two types of amphiphilic diblock copolymers, P(CL-g-CPT)-b-P(OEGMA-co-MAEBA)-C...