Determining the Predominant Conformations of Mortiamides A–D in Solution Using NMR Data and Molecular Modeling Tools

• Published in: ACS omega Vol. 8; no. 29; pp. 25832 - 25838
• Main Authors: Franca, Tanos C. C., Goncalves, Arlan da Silva, Bérubé, Christopher, Voyer, Normand, Aubry, Norman, LaPlante, Steven R.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.07.2023

Macrocyclic peptidomimetics have been seriously contributing to our arsenal of drugs to combat diseases. The search for nature’s discoveries led us to mortiamides A–D (found in a novel fungus from Northern Canada), which is a family of cyclic peptides that clearly have demonstrated impressive pharma...