pH-Assisted Gelation of Lactose-Modified Chitosan

We report on a controlled process allowing for the gelation of a diol-rich chitosan-derivative named CTL (lactose-modified chitosan) in the presence of boric acid as the cross-linker. A two-step approach is described, namely (i) the mixing of CTL and boric acid at pH = 5, a condition where the inorg...

Full description

Saved in:
Bibliographic Details
Published inBiomacromolecules Vol. 20; no. 8; pp. 3070 - 3075
Main Authors Sacco, Pasquale, Furlani, Franco, Paoletti, Sergio, Donati, Ivan
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 12.08.2019
Online AccessGet full text

Cover

Abstract We report on a controlled process allowing for the gelation of a diol-rich chitosan-derivative named CTL (lactose-modified chitosan) in the presence of boric acid as the cross-linker. A two-step approach is described, namely (i) the mixing of CTL and boric acid at pH = 5, a condition where the inorganic component is mildly reactive; (ii) the addition of sodium bicarbonate (NaHCO3) as a trigger, allowing for the gradual and slow pH increase. The goal was to convert gradually the almost inert neutral boric acid into the much more reactive borate anion, the latter promoting the formation of borate esters with CTL diols. Gelling kinetics as well as mechanical behavior at small and large deformations was investigated by rheometry. CTL-boric acid gels behaved essentially as transient networks, hence continuously assembling and dissociating in a highly dynamic fashion. The present gelling mechanism preserves the strain-hardening behavior in the nonlinear region of stress–strain response, corroborating the already suggested potential applications of such gels as mimics of biological soft tissues.
AbstractList We report on a controlled process allowing for the gelation of a diol-rich chitosan-derivative named CTL (lactose-modified chitosan) in the presence of boric acid as the cross-linker. A two-step approach is described, namely (i) the mixing of CTL and boric acid at pH = 5, a condition where the inorganic component is mildly reactive; (ii) the addition of sodium bicarbonate (NaHCO3) as a trigger, allowing for the gradual and slow pH increase. The goal was to convert gradually the almost inert neutral boric acid into the much more reactive borate anion, the latter promoting the formation of borate esters with CTL diols. Gelling kinetics as well as mechanical behavior at small and large deformations was investigated by rheometry. CTL-boric acid gels behaved essentially as transient networks, hence continuously assembling and dissociating in a highly dynamic fashion. The present gelling mechanism preserves the strain-hardening behavior in the nonlinear region of stress–strain response, corroborating the already suggested potential applications of such gels as mimics of biological soft tissues.
We report on a controlled process allowing for the gelation of a diol-rich chitosan-derivative named CTL (lactose-modified chitosan) in the presence of boric acid as the cross-linker. A two-step approach is described, namely (i) the mixing of CTL and boric acid at pH = 5, a condition where the inorganic component is mildly reactive; (ii) the addition of sodium bicarbonate (NaHCO ) as a trigger, allowing for the gradual and slow pH increase. The goal was to convert gradually the almost inert neutral boric acid into the much more reactive borate anion, the latter promoting the formation of borate esters with CTL diols. Gelling kinetics as well as mechanical behavior at small and large deformations was investigated by rheometry. CTL-boric acid gels behaved essentially as transient networks, hence continuously assembling and dissociating in a highly dynamic fashion. The present gelling mechanism preserves the strain-hardening behavior in the nonlinear region of stress-strain response, corroborating the already suggested potential applications of such gels as mimics of biological soft tissues.
Author Paoletti, Sergio
Sacco, Pasquale
Furlani, Franco
Donati, Ivan
AuthorAffiliation Department of Life Sciences
AuthorAffiliation_xml – name: Department of Life Sciences
Author_xml – sequence: 1
  givenname: Pasquale
  orcidid: 0000-0002-4483-5099
  surname: Sacco
  fullname: Sacco, Pasquale
  email: psacco@units.it
– sequence: 2
  givenname: Franco
  orcidid: 0000-0001-5986-1727
  surname: Furlani
  fullname: Furlani, Franco
– sequence: 3
  givenname: Sergio
  surname: Paoletti
  fullname: Paoletti, Sergio
– sequence: 4
  givenname: Ivan
  orcidid: 0000-0003-3752-8346
  surname: Donati
  fullname: Donati, Ivan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31268693$$D View this record in MEDLINE/PubMed
BookMark eNp9kD1PwzAURS1URD_gDzCgjiwJ_ojteKwqaJGCWGC2nh1HuEriEicD_56UFEamZz2fe6V3lmjWhtYhdEtwSjAlD2BjanxowKbKYCyYuEALwqlIMoHp7OfNEymVnKNljAeMsWIZv0JzRqjIhWILRI77ZBOjj70r1ztXQ-9Duw7VugDbh-iSl1D6yo-f2w8_LqC9RpcV1NHdnOcKvT89vm33SfG6e95uigRYLvrEAMmUlECJkQosFlxRzEsOCoStMgV5pQhIIDnPTO4ErRzDObeGZJmx1rEVup96j134HFzsdeOjdXUNrQtD1JRySoVkXIwonVDbhRg7V-lj5xvovjTB-qRKj6r0pEqfVY2hu3P_YBpX_kV-3YxAOgGn8CEMXTue-1_jN96GdyQ
CitedBy_id crossref_primary_10_3390_gels8030194
crossref_primary_10_1016_j_carbpol_2019_115641
crossref_primary_10_1016_j_mtchem_2022_101222
crossref_primary_10_1021_acs_analchem_1c01636
crossref_primary_10_3390_molecules25071534
crossref_primary_10_3390_gels10020094
crossref_primary_10_1002_adfm_202200309
crossref_primary_10_1016_j_carbpol_2022_120369
crossref_primary_10_3390_ijms21186831
crossref_primary_10_3390_ijms23158245
crossref_primary_10_1002_mabi_202000236
crossref_primary_10_1016_j_ijbiomac_2021_11_075
crossref_primary_10_1016_j_aca_2021_338958
crossref_primary_10_1021_acsbiomaterials_9b01256
crossref_primary_10_1016_j_carbpol_2020_116845
crossref_primary_10_1021_acs_biomac_1c00293
crossref_primary_10_1021_acs_analchem_0c04927
crossref_primary_10_2147_IJN_S368458
crossref_primary_10_1039_D0NA00758G
Cites_doi 10.1122/1.4979368
10.1002/9783527639328
10.1021/ma1029532
10.1016/j.biomaterials.2014.06.047
10.1038/ncomms7365
10.1002/advs.201800638
10.1021/mz4005106
10.1021/acs.biomac.7b01237
10.1016/j.carbpol.2017.06.097
10.1096/fj.05-5424rev
10.1016/0377-0257(88)80002-8
10.1016/j.carres.2007.08.021
10.1122/1.550391
10.1021/acs.chemrev.5b00300
10.1021/bm100136y
10.3390/gels4030067
10.1016/j.bpj.2016.10.002
10.1038/nature03521
10.1021/ma00051a043
10.1021/acs.macromol.6b00959
10.1038/nature23673
10.1038/nmat4489
10.1038/nature10316
10.1021/jacs.5b00722
10.1016/j.ijbiomac.2017.08.059
10.1038/nmat4993
10.1016/j.biomaterials.2004.04.015
10.1016/j.actbio.2018.03.041
10.1021/ma400600f
10.1021/bm3002683
10.1016/S0144-8617(00)00343-X
10.1016/j.carbpol.2018.12.096
10.1063/1.3498779
10.1038/s41467-018-02906-9
ContentType Journal Article
DBID NPM
AAYXX
CITATION
7X8
DOI 10.1021/acs.biomac.9b00636
DatabaseName PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList
PubMed
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1526-4602
EndPage 3075
ExternalDocumentID 10_1021_acs_biomac_9b00636
31268693
a75549353
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID -
02
23N
53G
55A
5GY
7~N
AABXI
ABFLS
ABMVS
ABPTK
ABUCX
ACGFS
ACS
AEESW
AENEX
AFEFF
ALMA_UNASSIGNED_HOLDINGS
AQSVZ
CS3
DU5
EBS
ED
ED~
EJD
F5P
GNL
IH9
JG
JG~
P2P
RNS
ROL
RSW
TN5
UI2
VF5
VG9
W1F
X
XKZ
---
-~X
4.4
5VS
AAHBH
ABJNI
ABQRX
ADHLV
AHGAQ
BAANH
CUPRZ
GGK
NPM
ZCA
~02
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-a386t-ba14977a21b79ac0659205d5a9a6cf49a8f91a7a1854b8e62fe3085cb144bcce3
IEDL.DBID ACS
ISSN 1525-7797
IngestDate Thu Aug 15 23:48:35 EDT 2024
Fri Aug 23 04:02:31 EDT 2024
Sat Sep 28 08:27:57 EDT 2024
Thu Aug 27 13:44:19 EDT 2020
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a386t-ba14977a21b79ac0659205d5a9a6cf49a8f91a7a1854b8e62fe3085cb144bcce3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-4483-5099
0000-0003-3752-8346
0000-0001-5986-1727
OpenAccessLink https://arts.units.it/bitstream/11368/2952839/5/ab9b01256_si_001.pdf
PMID 31268693
PQID 2252267356
PQPubID 23479
PageCount 6
ParticipantIDs proquest_miscellaneous_2252267356
crossref_primary_10_1021_acs_biomac_9b00636
pubmed_primary_31268693
acs_journals_10_1021_acs_biomac_9b00636
ProviderPackageCode JG~
55A
AABXI
GNL
VF5
XKZ
7~N
VG9
W1F
ACS
AEESW
AFEFF
ABMVS
ABUCX
IH9
AQSVZ
ED~
UI2
PublicationCentury 2000
PublicationDate 2019-08-12
PublicationDateYYYYMMDD 2019-08-12
PublicationDate_xml – month: 08
  year: 2019
  text: 2019-08-12
  day: 12
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Biomacromolecules
PublicationTitleAlternate Biomacromolecules
PublicationYear 2019
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
References ref9/cit9
ref6/cit6
ref3/cit3
ref27/cit27
ref18/cit18
ref11/cit11
ref25/cit25
ref16/cit16
ref29/cit29
Hall D. G. (ref17/cit17) 2011
ref32/cit32
ref23/cit23
ref14/cit14
ref8/cit8
ref5/cit5
ref31/cit31
ref2/cit2
ref34/cit34
ref28/cit28
ref20/cit20
ref10/cit10
ref26/cit26
ref19/cit19
ref21/cit21
ref12/cit12
ref15/cit15
ref22/cit22
ref13/cit13
ref33/cit33
ref4/cit4
ref30/cit30
ref1/cit1
ref24/cit24
ref7/cit7
References_xml – ident: ref30/cit30
  doi: 10.1122/1.4979368
– start-page: 1
  volume-title: Boronic Acids
  year: 2011
  ident: ref17/cit17
  doi: 10.1002/9783527639328
  contributor:
    fullname: Hall D. G.
– ident: ref32/cit32
  doi: 10.1021/ma1029532
– ident: ref2/cit2
  doi: 10.1016/j.biomaterials.2014.06.047
– ident: ref4/cit4
  doi: 10.1038/ncomms7365
– ident: ref6/cit6
  doi: 10.1002/advs.201800638
– ident: ref27/cit27
  doi: 10.1021/mz4005106
– ident: ref15/cit15
  doi: 10.1021/acs.biomac.7b01237
– ident: ref19/cit19
  doi: 10.1016/j.carbpol.2017.06.097
– ident: ref10/cit10
  doi: 10.1096/fj.05-5424rev
– ident: ref22/cit22
  doi: 10.1016/0377-0257(88)80002-8
– ident: ref21/cit21
  doi: 10.1016/j.carres.2007.08.021
– ident: ref28/cit28
  doi: 10.1122/1.550391
– ident: ref18/cit18
  doi: 10.1021/acs.chemrev.5b00300
– ident: ref33/cit33
  doi: 10.1021/bm100136y
– ident: ref11/cit11
  doi: 10.3390/gels4030067
– ident: ref3/cit3
  doi: 10.1016/j.bpj.2016.10.002
– ident: ref34/cit34
  doi: 10.1038/nature03521
– ident: ref31/cit31
  doi: 10.1021/ma00051a043
– ident: ref25/cit25
  doi: 10.1021/acs.macromol.6b00959
– ident: ref8/cit8
  doi: 10.1038/nature23673
– ident: ref1/cit1
  doi: 10.1038/nmat4489
– ident: ref9/cit9
  doi: 10.1038/nature10316
– ident: ref24/cit24
  doi: 10.1021/jacs.5b00722
– ident: ref29/cit29
  doi: 10.1016/j.ijbiomac.2017.08.059
– ident: ref5/cit5
  doi: 10.1038/nmat4993
– ident: ref12/cit12
  doi: 10.1016/j.biomaterials.2004.04.015
– ident: ref14/cit14
  doi: 10.1016/j.actbio.2018.03.041
– ident: ref23/cit23
  doi: 10.1021/ma400600f
– ident: ref13/cit13
  doi: 10.1021/bm3002683
– ident: ref20/cit20
  doi: 10.1016/S0144-8617(00)00343-X
– ident: ref16/cit16
  doi: 10.1016/j.carbpol.2018.12.096
– ident: ref26/cit26
  doi: 10.1063/1.3498779
– ident: ref7/cit7
  doi: 10.1038/s41467-018-02906-9
SSID ssj0009345
Score 2.4458363
Snippet We report on a controlled process allowing for the gelation of a diol-rich chitosan-derivative named CTL (lactose-modified chitosan) in the presence of boric...
SourceID proquest
crossref
pubmed
acs
SourceType Aggregation Database
Index Database
Publisher
StartPage 3070
Title pH-Assisted Gelation of Lactose-Modified Chitosan
URI http://dx.doi.org/10.1021/acs.biomac.9b00636
https://www.ncbi.nlm.nih.gov/pubmed/31268693
https://search.proquest.com/docview/2252267356
Volume 20
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT8MwDI7GOMCF92O8VCQkDtDRNGnSHqeKMSHGBSbtViVpIhBSO9Huwq_H6QOEYGjXKLISO7E_x7GN0AWVRrCAald7TLuUUwZXSlGXK54qLxTEeDY5efzIRhN6Pw2mHXS9IILv4xuhir5NRQfytn4fI2wFrfpgGK2rNYifvkvskqolsW3oA5gx4k2KzN80rDFSxU9jtABhVpZmuInGbb5O_cHkrT8vZV99_C7fuNQmttBGAzmdQX1GtlFHZztoLW47ve0iPBu5ICYr8NS5a37HOblxHmwznkK74zx9NYBVnfgFFEAhsj00Gd4-xyO3aaXgChKy0pUCPCHOhY8lj4SqgqlekAYiEkwZGonQRFhwAdabylAz32gCYExJ8LekUprso26WZ_oQOSplHKeGgzowNEyJZIHGnsahTD0JaKGHLmG3SXMViqSKcvs4sYM1C5KGBT101XI_mdW1Nf6dfd4KKAH-2LiGyHQ-LxJQSQAiOQlgzkEtuS96BPssZBE5WnpVx2gdQFFk342xf4K65ftcnwLwKOVZdd4-AfS40ak
link.rule.ids 315,786,790,2782,27107,27955,27956,57091,57141
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LT8MwDI5gHMaF92M8i4TEARWaJk3aI5oYBbZd2KTdqiRNBELqJtpd-PU4bbcJBAiuUeQ6dmJ_qWMboXMqjWAB1a72mHYppwyOlKIuVzxVXiiI8Wxycq_P4iF9GAWjOo_b5sIAEzlQyssg_qK6AL62YzYjHb5iy_gxwpbRSsDB3Vk81H5aVNolZWdi29cHoGPE60yZ72lYn6Tyzz7pB6BZOpzOOhrMWS3fmbxeTQt5pd6_VHH851o20FoNQJ2basdsoiWdbaFme9b3bRvhSeyC0qz6U-eufivnjI3Tta15cu32xumLAeTqtJ_BHOQi20HDzu2gHbt1YwVXkJAVrhRwL-Jc-FjySKgytOoFaSAiwZShkQhNhAUX4MupDDXzjSYAzZSE25dUSpNd1MjGmd5HjkoZx6nhYBwMDVMiWaCxp3EoU08CdmihC1htUh-MPClj3j5O7GAlgqQWQQtdzpSQTKpKG7_OPpvpKQH52CiHyPR4midgoABSchLAnL1KgXN6BPssZBE5-DNXp6gZD3rdpHvffzxEqwCXIvtHGftHqFG8TfUxQJJCnpRb8AP-VtoU
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LSwMxEA5aQb34ftTnCoIH2brZZJPdY6nWqm0RtNDbkieKsC1ue_HXO9luK4qKeA1hMslkMl8ymRmETqm0gkXU-CZgxqecMlApRX2uuFZBLIgNXHByp8taPXrbj_rl04WLhQEmcqCUF058p9VDbcsMA_jCtbuodBjJpfJjhM2jhYhj6jSy3nj4yLZLiurErrYPwMeEl9Ey39Nwdknln-3SD2CzMDrNVdSfsVv8NXmpjUeypt6-ZHL8x3zW0EoJRL36ZOesozmTbaClxrT-2ybCw5YPwnPbQHvX5Z85b2C9tivRkxu_M9DPFhCs13iCYyEX2RbqNa8eGy2_LLDgCxKzkS8F3I84FyGWPBGqcLEGkY5EIpiyNBGxTbDgAmw6lbFhoTUEIJqScAuTShmyjSrZIDO7yFOacawth0PC0lgTySKDA4NjqQMJGKKKzmC2aakgeVr4vkOcusbJEqTlElTR-VQQ6XCScePX3idTWaWwPs7bITIzGOcpHFQALTmJoM_ORIgzegSHLGYJ2fszV8do8f6ymbZvunf7aBlQU-IelnF4gCqj17E5BGQykkfFLnwHIbDcjg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=pH-Assisted+Gelation+of+Lactose-Modified+Chitosan&rft.jtitle=Biomacromolecules&rft.au=Sacco%2C+Pasquale&rft.au=Furlani%2C+Franco&rft.au=Paoletti%2C+Sergio&rft.au=Donati%2C+Ivan&rft.date=2019-08-12&rft.eissn=1526-4602&rft.volume=20&rft.issue=8&rft.spage=3070&rft_id=info:doi/10.1021%2Facs.biomac.9b00636&rft_id=info%3Apmid%2F31268693&rft.externalDocID=31268693
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1525-7797&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1525-7797&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1525-7797&client=summon