Ageritin, a Ribotoxin from Poplar Mushroom (Agrocybe aegerita) with Defensive and Antiproliferative Activities

• Published in: ACS chemical biology Vol. 14; no. 6; pp. 1319 - 1327
• Main Authors: Citores, Lucía, Ragucci, Sara, Ferreras, José M, Di Maro, Antimo, Iglesias, Rosario
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.06.2019
• Subjects: Agrocybe - chemistry; Anti-Infective Agents - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; Cytotoxins - pharmacology; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Micrococcus - drug effects; Ribonucleases - isolation & purification; Ribonucleases - pharmacology; Tobacco Mosaic Virus - drug effects

Ribotoxins make up a group of extracellular rRNA endoribonucleases produced by ascomycetes that display cytotoxicity toward animal cells, having been proposed as insecticidal agents. Recently, the ribotoxin Ageritin has been isolated from the basidiomycetes Agrocybe aegerita (poplar mushroom), sugge...