Tailoring Oxidation Responsiveness of Gold Nanoclusters via Ligand Engineering for Imaging Acute Kidney Injury

• Published in: Analytical chemistry (Washington) Vol. 95; no. 44; pp. 16153 - 16159
• Main Authors: Li, Shihua, Yang, Nangen, Ma, Qiuping, Li, Shijie, Tong, Shufen, Luo, Jiewei, Song, Xiaorong, Yang, Huanghao
• Format: Journal Article
• Language: English
• Published: Washington American Chemical Society 07.11.2023
• Subjects: Acetylcysteine; acute kidney injury; analytical chemistry; Anions; bioimaging; Biomedical materials; Cyclodextrins; Glomerular filtration rate; Gold; Injuries; Kidneys; Ligands; Macromolecules; Medical imaging; Nanoclusters; nanogold; Near infrared radiation; Oxidation; Photoluminescence; Photons; renal clearance; β-Cyclodextrin

Gold nanoclusters (AuNCs) have shown great promise for in vivo imaging because of their definable structure, tunable photoluminescence (PL), and desired renal clearance. However, current understanding of the responsiveness of AuNCs to biological substances is still limited, which may hamper their bi...