Real-Time Visualization of Embryonic Apoptosis Using a Near-Infrared Fluorogenic Probe for Embryo Development Evaluation

• Published in: Analytical chemistry (Washington) Vol. 93; no. 35; pp. 12122 - 12130
• Main Authors: He, Lei, Ye, Shuyue, Fang, Jing, Zhang, Yuqi, Cui, Chaoxiang, Wang, Anna, Zhao, Yan, Shi, Haibin
• Format: Journal Article
• Language: English
• Published: Washington American Chemical Society 07.09.2021
• Subjects: analytical chemistry; Apoptosis; Aqueous solutions; Caspase-3; Chemistry; Embryogenesis; Embryonic growth stage; Embryos; Fluorescence; fluorescent dyes; I.R. radiation; Near infrared radiation; peptides; Real time; Substrates; Visualization

Developing an accurate and reliable detection technique for early embryonic apoptosis is of great significance for real-time monitoring and evaluation of embryonic development in living systems. Herein, we have rationally designed and synthesized a novel near-infrared (NIR) fluorogenic probe CGK­(QS...