RPA-CRISPR-Cas-Mediated Dual Lateral Flow Assay for the Point-of-Care Testing of HPV16 and HPV18

• Published in: Bioconjugate chemistry Vol. 35; no. 11; pp. 1797 - 1804
• Main Authors: Zhang, Kaini, Li, Qingmei, Wang, Kun, Zhang, Qiaoli, Ma, Chengkun, Yang, Guiwen, Xie, Yanxia, Mauk, Michael G., Fu, Shanji, Chen, Lei
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 20.11.2024
• Subjects: Cancer; Cervical cancer; CRISPR; CRISPR-Cas Systems - genetics; Female; Human papillomavirus; Human papillomavirus 16 - genetics; Human papillomavirus 18 - genetics; Humans; Nucleic acids; Papillomavirus Infections - diagnosis; Papillomavirus Infections - virology; Point of care testing; Self testing; Sensitivity; Sensitivity analysis

The incidence of cervical cancer caused by human papillomavirus (HPV) infection has increased in recent years. More than half of all cervical cancer cases are due to HPV16 and HPV18 infection, so HPV16 and HPV18 testing is essential to prevent cervical cancer. HPV testing is mainly carried out in ho...