Magnetically Guided Viral Transduction of Gene-Based Sensitization for Localized Photodynamic Therapy To Overcome Multidrug Resistance in Breast Cancer Cells

• Published in: Bioconjugate chemistry Vol. 28; no. 6; pp. 1702 - 1708
• Main Authors: Liao, Zi-Xian, Kempson, Ivan M, Fa, Yu-Chen, Liu, Meng-Chia, Hsieh, Li-Chen, Huang, Kuo-Yen, Wang, Li-Feng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.06.2017
• Subjects: Adenoviridae - genetics; Breast cancer; Breast Neoplasms - pathology; Cancer; Cell Line, Tumor; Cells; Chemotherapy; Drug metabolism; Drug resistance; Drug Resistance, Multiple - radiation effects; Efflux; Female; Genes; Genomes; Humans; Magnetics; Magnetism; Metabolism; Multidrug resistance; Photochemotherapy - methods; Photodynamic therapy; Photosensitivity; Radiation therapy; Signal transduction; Surgery; Transduction, Genetic - methods; Viruses

Chemotherapy represents a conventional treatment for many cancers at different stages and is either solely prescribed or concomitant to surgery, radiotherapy, or both. However, treatment is tempered in instances of acquired drug resistance in response to either chemotherapy or targeted therapy, lead...