Lactoferrin Coupled Lower Generation PAMAM Dendrimers for Brain Targeted Delivery of Memantine in Aluminum-Chloride-Induced Alzheimer’s Disease in Mice

• Published in: Bioconjugate chemistry Vol. 30; no. 10; pp. 2573 - 2583
• Main Authors: Gothwal, Avinash, Kumar, Hitesh, Nakhate, Kartik T, Ajazuddin, Dutta, Ankumoni, Borah, Anupom, Gupta, Umesh
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 16.10.2019
• Subjects: Acetylcholinesterase; Aluminum; Aluminum chloride; Alzheimer's disease; Bioavailability; Biocompatibility; Brain; Conjugates; Dendrimers; Dihydroxyphenylacetic acid; Dopamine; Drug delivery; Drug delivery systems; In vivo methods and tests; Lactoferrin; Memantine; Mice; Neurodegenerative diseases; Optical density; Toxicity; Zeta potential

Lower generation PAMAM dendrimers have an immense potential for drug delivery with lower toxicity, but these dendrimers yet need certain basic ameliorations. In this study, the brain delivery potential of the synthesized PAMAM-Lf (lower generation PAMAM and lactoferrin conjugate) loaded with memanti...