Photocontrolled Release of Doxorubicin Conjugated through a Thioacetal Photocage in Folate-Targeted Nanodelivery Systems

• Published in: Bioconjugate chemistry Vol. 28; no. 12; pp. 3016 - 3028
• Main Authors: Wong, Pamela T, Tang, Shengzhuang, Cannon, Jayme, Chen, Dexin, Sun, Rachel, Lee, Jennifer, Phan, James, Tao, Ke, Sun, Kang, Chen, Biqiong, Baker, James R, Choi, Seok Ki
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 20.12.2017; Amer Chemical Soc
• Subjects: Aqueous solutions; Biochemical Research Methods; Biochemistry & Molecular Biology; Cells; Chemistry; Chemistry, Multidisciplinary; Chemistry, Organic; Conjugation; Core-shell structure; Crosslinking; Cytotoxicity; Doxorubicin; Drug delivery systems; Experiments; Folic acid; I.R. radiation; Infrared radiation; Kinetics; Life Sciences & Biomedicine; Nanoparticles; Nanostructure; Physical Sciences; Protoporphyrin; Protoporphyrin IX; Science & Technology; Toxicity; Ultraviolet radiation; Upconversion; GOLD NANOPARTICLES; IN-VITRO; VANCOMYCIN; DENDRIMER; SURFACE; UP-CONVERSION NANOPARTICLES; CONTROLLED DRUG-RELEASE; ANTICANCER DRUGS; SIRNA DELIVERY; EFFICIENT

Despite their proven ability for precise and targeted release, nanoplatform systems for photocontrolled delivery often face formidable synthetic challenges, in part due to the paucity of advanced linker strategies. Here, we report on a novel linker strategy using a thioacetal ortho-nitrobenzaldehyde...