Neurotrophic Effects of Vascular Endothelial Growth Factor B and Novel Mimetic Peptides on Neurons from the Central Nervous System

• Published in: ACS chemical neuroscience Vol. 11; no. 9; pp. 1270 - 1282
• Main Authors: Dmytriyeva, Oksana, de Diego Ajenjo, Amaia, Lundø, Kathrine, Hertz, Henrik, Rasmussen, Kim K, Christiansen, Anders T, Klingelhofer, Jorg, Nielsen, Alexander L, Hoeber, Jan, Kozlova, Elena, Woldbye, David P. D, Pankratova, Stanislava
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.05.2020
• Subjects: neurite outgrowth; neuronal survival; peptide; VEGFB; VEGFB; peptide; neurite outgrowth; neuronal survival

Vascular endothelial growth factor B (VEGFB) is a pleiotropic trophic factor, which in contrast to the closely related VEGFA is known to have a limited effect on angiogenesis. VEGFB improves survival in various tissues including the nervous system, where the effect was observed mainly for peripheral...