Lycopene Prevents Mitochondrial Dysfunction during d‑Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Albino Rats

• Published in: Journal of proteome research Vol. 16; no. 9; pp. 3190 - 3199
• Main Authors: Sheriff, Sheik Abdulazeez, Shaik Ibrahim, Shaikhussain, Devaki, Thiruvengadam, Chakraborty, Sandipan, Agarwal, Subhash, Pérez-Sánchez, Horacio
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.09.2017
• Subjects: adenosine triphosphate; Adenosine Triphosphate - agonists; Adenosine Triphosphate - antagonists & inhibitors; Adenosine Triphosphate - biosynthesis; albino; Animals; antioxidant activity; Antioxidants - chemistry; Antioxidants - pharmacology; Binding Sites; body weight; Carotenoids - chemistry; Carotenoids - pharmacology; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - pathology; Citric Acid Cycle - drug effects; electron transport chain; Electron Transport Chain Complex Proteins - agonists; Electron Transport Chain Complex Proteins - antagonists & inhibitors; Electron Transport Chain Complex Proteins - metabolism; enzyme activity; enzymes; Galactosamine - toxicity; hydrogen peroxide; Hydrogen Peroxide - antagonists & inhibitors; Hydrogen Peroxide - metabolism; lipid peroxidation; Lipid Peroxidation - drug effects; lipid peroxides; Lipopolysaccharides - toxicity; Lipoxygenase Inhibitors - chemistry; Lipoxygenase Inhibitors - pharmacology; Lipoxygenases - chemistry; Lipoxygenases - metabolism; Liver; liver failure; Liver Failure, Acute - chemically induced; Liver Failure, Acute - drug therapy; Liver Failure, Acute - metabolism; Liver Failure, Acute - pathology; lungs; lycopene; Male; mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; mitochondrial membrane; Molecular Docking Simulation; molecular models; neoplasms; Oxidative Stress; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; proteome; Rats; Rats, Wistar; toxicity; tricarboxylic acid cycle; electron transport; free radicals; TCA Cycle; lipid peroxidation; ATP

Functional perturbation of mitochondria is associated with fulminant hepatic failure (FHF). d-Galactosamine/lipopolysaccharide (d-GalN/LPS)-induced FHF is a renowned model to evaluate the efficacy of hepatoprotective agents. Lycopene is an antioxidant and phytonutrient from the carotenoid family. Th...