UPLC–QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis

• Published in: Journal of proteome research Vol. 19; no. 2; pp. 600 - 609
• Main Authors: Guan, Su, Jia, Bingjie, Chao, Kang, Zhu, Xia, Tang, Jian, Li, Miao, Wu, Lvying, Xing, Lei, Liu, Kun, Zhang, Lei, Wang, Xueding, Gao, Xiang, Huang, Min
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.02.2020
• Subjects: alpha-carotene; arachidonic acid; bile acids; biomarkers; biosynthesis; blood lipids; docosahexaenoic acid; early diagnosis; inflammatory bowel disease; lipid composition; lipid metabolism; mass spectrometry; metabolites; multivariate analysis; palmitic acid; patients; principal component analysis; proteome; sphingolipids; sterols; ultra-performance liquid chromatography; plasma; biomarkers; inflammatory bowel disease; lipidomics; metabolic pathways

Identification of new biomarkers may help in the early diagnosis of inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC–QTOF-MS) was used to analyze the untargeted lipidomics and compare plasma l...