Feasibility of Early Detection of Cystic Fibrosis Acute Pulmonary Exacerbations by Exhaled Breath Condensate Metabolomics: A Pilot Study

• Published in: Journal of proteome research Vol. 16; no. 2; pp. 550 - 558
• Main Authors: Zang, Xiaoling, Monge, María Eugenia, McCarty, Nael A, Stecenko, Arlene A, Fernández, Facundo M
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 03.02.2017
• Subjects: Adolescent; Adult; Biomarkers - metabolism; Breath Tests; Chromatography, Liquid; condensates; Cyclohexanes - metabolism; cystic fibrosis; Cystic Fibrosis - diagnosis; Cystic Fibrosis - metabolism; Cystic Fibrosis - physiopathology; death; Early Diagnosis; Exhalation; Female; Humans; lactic acid; Lactic Acid - metabolism; liquid chromatography; lung function; Male; Mass Spectrometry; metabolites; metabolomics; Metabolomics - methods; monitoring; patients; Pilot Projects; prediction; proteome; Pyrrolidonecarboxylic Acid - metabolism; Severity of Illness Index; ultraperformance liquid chromatography mass spectrometry; metabolomics; cystic fibrosis; acute pulmonary exacerbations

Progressive lung function decline and, ultimately, respiratory failure are the most common cause of death in patients with cystic fibrosis (CF). This decline is punctuated by acute pulmonary exacerbations (APEs), and in many cases, there is a failure to return to baseline lung function. Ultraperform...