インクレチンの生理作用と機能性食品成分による調節・模倣

食事による血糖上昇に対応して適切にインスリンが分泌されて適切に作用することで血糖の恒常性が維持される。特にインスリン分泌能が低い東アジア人では, インスリン分泌を担う膵β細胞の機能維持が2型糖尿病を予防するために重要な課題となっている。腸管インクレチンホルモンであるgastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) とglucagon-like peptide (GLP-1) は, 膵β細胞に直接あるいは間接的に作用して, 膵β細胞の細胞増殖促進作用, 細胞死抑制作用, 血糖上昇に対...

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Published inNihon Eiyō, Shokuryō Gakkai shi Vol. 76; no. 3; pp. 141 - 147
Main Author 原田, 直樹
Format Journal Article
LanguageJapanese
Published 公益社団法人 日本栄養・食糧学会 2023
日本栄養・食糧学会
Subjects
インクレチン
インスリン
機能性食品成分
腸管内分泌細胞
膵β細胞
Online AccessGet full text
ISSN0287-3516
1883-2849
DOI10.4327/jsnfs.76.141

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Abstract 食事による血糖上昇に対応して適切にインスリンが分泌されて適切に作用することで血糖の恒常性が維持される。特にインスリン分泌能が低い東アジア人では, インスリン分泌を担う膵β細胞の機能維持が2型糖尿病を予防するために重要な課題となっている。腸管インクレチンホルモンであるgastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) とglucagon-like peptide (GLP-1) は, 膵β細胞に直接あるいは間接的に作用して, 膵β細胞の細胞増殖促進作用, 細胞死抑制作用, 血糖上昇に対応したインスリン分泌増幅作用を発揮する。インクレチンの血糖恒常性維持機構を利用した応用展開は, 2型糖尿病薬にとどまらず, 健康食品や食事自体による予防にも役立つと考えられる。本稿では, インスリン, インクレチンホルモンと2型糖尿病について概説し, インクレチンの分泌を促進あるいは作用を模倣する機能性食品成分について紹介する。
AbstractList 食事による血糖上昇に対応して適切にインスリンが分泌されて適切に作用することで血糖の恒常性が維持される。特にインスリン分泌能が低い東アジア人では，インスリン分泌を担う膵β細胞の機能維持が2型糖尿病を予防するために重要な課題となっている。腸管インクレチンホルモンであるgastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide(GIP)とglucagon-like peptide(GLP-1)は，膵β細胞に直接あるいは間接的に作用して，膵β細胞の細胞増殖促進作用，細胞死抑制作用，血糖上昇に対応したインスリン分泌増幅作用を発揮する。インクレチンの血糖恒常性維持機構を利用した応用展開は，2型糖尿病薬にとどまらず，健康食品や食事自体による予防にも役立つと考えられる。本稿では，インスリン，インクレチンホルモンと2型糖尿病について概説し，インクレチンの分泌を促進あるいは作用を模倣する機能性食品成分について紹介する。
食事による血糖上昇に対応して適切にインスリンが分泌されて適切に作用することで血糖の恒常性が維持される。特にインスリン分泌能が低い東アジア人では, インスリン分泌を担う膵β細胞の機能維持が2型糖尿病を予防するために重要な課題となっている。腸管インクレチンホルモンであるgastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) とglucagon-like peptide (GLP-1) は, 膵β細胞に直接あるいは間接的に作用して, 膵β細胞の細胞増殖促進作用, 細胞死抑制作用, 血糖上昇に対応したインスリン分泌増幅作用を発揮する。インクレチンの血糖恒常性維持機構を利用した応用展開は, 2型糖尿病薬にとどまらず, 健康食品や食事自体による予防にも役立つと考えられる。本稿では, インスリン, インクレチンホルモンと2型糖尿病について概説し, インクレチンの分泌を促進あるいは作用を模倣する機能性食品成分について紹介する。
「要旨」:食事による血糖上昇に対応して適切にインスリンが分泌されて適切に作用することで血糖の恒常性が維持される. 特にインスリン分泌能が低い東アジア人では, インスリン分泌を担う膵β細胞の機能維持が2型糖尿病を予防するために重要な課題となっている. 腸管インクレチンホルモンであるgastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP)とglucagon-like peptide (GLP-1)は, 膵β細胞に直接あるいは間接的に作用して, 膵β細胞の細胞増殖促進作用, 細胞死抑制作用, 血糖上昇に対応したインスリン分泌増幅作用を発揮する. インクレチンの血糖恒常性維持機構を利用した応用展開は, 2型糖尿病薬にとどまらず, 健康食品や食事自体による予防にも役立つと考えられる. 本稿では, インスリン, インクレチンホルモンと2型糖尿病について概説し, インクレチンの分泌を促進あるいは作用を模倣する機能性食品成分について紹介する.
Author 原田, 直樹
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References_xml – reference: 6) Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-10.
– reference: 24) Shirazi-Beechey SP, Daly K. Al-Rammahi M, Moran AW, Bravo D (2014) Role of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing. Br J Nutr 111: S8-15.
– reference: 11) Perley MJ, Kipnis DM (1967) Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic sujbjects. J Clin Invest 46: 1954-62.
– reference: 38) Baker M (2017) Deceptive curcumin offers cautionary tale for chemists. Nature 541: 144-5.
– reference: 37) Harada N, Arahori Y, Okuyama M, Luis PB, Joseph AI, Kitakaze T, Goshima N, Schneider C, Inui H, Yamaji R (2022) Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid. Biochem Biophys Res Commun 595: 41-6.
– reference: 20) Frías JP, Davies MJ, Rosenstock J, Pérez Manghi FC, Fernández Landó L, Bergman BK, Liu B, Cui X, Brown K (2021) Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes. New Engl J Med 385: 503-15.
– reference: 36) Harada N, Okuyama M, Teraoka Y, Arahori Y, Shinmori Y, Horiuchi H, Luis PB, Joseph AI, Kitakaze T, Matsumura S, Hira T, Yamamoto N, Inui T, Goshima N, Schneider C, Inui H, Yamaji R (2022) Identification of G-protein coupled receptor 55 (GPR55) as a target of curcumin. NPJ Sci Food 6: 4.
– reference: 39) Tang J, Wan Y, Zhao M, Zhong H, Zheng JS, Feng F (2020) Legume and soy intake and risk of type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. Am J Clin Nutr 111: 677-88.
– reference: 30) 堀内寛子, 原田直樹, 山地亮一 (2015) 膵β細胞のインスリン分泌能におよぼすポリフェノール類の作用. ビタミン 89: 341-7.
– reference: 42) Dong HL, Tang XY, Deng YY, Zhong QW, Wang C, Zhang ZQ, Chen YM (2020) Urinary equol, but not daidzein and genistein, was inversely associated with the risk of type 2 diabetes in Chinese adults. Eur J Nutr 59: 719-728.
– reference: 29) Katsuma S, Hirasawa A, Tsujimoto G (2005) Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem Biophys Res Commun 329: 386-90.
– reference: 10) Yalow RS, Berson SA (1960) Immunoassay of endogenous plasma insulin in man. J Clin Invest 39: 1157-75.
– reference: 15) Nauck M, Stockmann F, Ebert R, Creutzfeldt W (1986) Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 29: 46-52.
– reference: 48) Kazeem M, Bankole H, Ogunrinola O, Wusu A, Kappo A (2021) Functional foods with dipeptidyl peptidase-4 inhibitory potential and management of type 2 diabetes: A review. Food Front 2: 153-62.
– reference: 31) Esatbeyoglu T, Huebbe P, Ernst IM, Chin D, Wagner AE, Rimbach G (2012) Curcumin―from molecule to biological function. Angew Chem Int Ed Engl 51: 5308-32.
– reference: 16) Holst JJ, Knop FK, Vilsbøll T, Krarup T, Madsbad S (2011) Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes. Diabetes Care 34: S251-7.
– reference: 33) Altobelli E, Angeletti PM, Marziliano C, Mastrodomenico M, Giuliani AR, Petrocelli R (2021) Potential therapeutic effects of curcumin on glycemic and lipid profile in uncomplicated type 2 diabetes-a meta-analysis of randomized controlled trial. Nutrients 13: 404.
– reference: 22) Kim YG, Hahn S, Oh TJ, Kwak SH, Park KS, Cho YM (2013) Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and non-Asians: a systematic review and meta-analysis. Diabetologia 56: 696-708.
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Snippet 食事による血糖上昇に対応して適切にインスリンが分泌されて適切に作用することで血糖の恒常性が維持される。特にインスリン分泌能が低い東アジア人では, インスリン分泌を担う膵β細胞の機能維持が2型糖尿病を予防するために重要な課題となっている。腸管インクレチンホルモンであるgastric inhibitory...
「要旨」:食事による血糖上昇に対応して適切にインスリンが分泌されて適切に作用することで血糖の恒常性が維持される. 特にインスリン分泌能が低い東アジア人では, インスリン分泌を担う膵β細胞の機能維持が2型糖尿病を予防するために重要な課題となっている. 腸管インクレチンホルモンであるgastric inhibitory...
食事による血糖上昇に対応して適切にインスリンが分泌されて適切に作用することで血糖の恒常性が維持される。特にインスリン分泌能が低い東アジア人では，インスリン分泌を担う膵β細胞の機能維持が2型糖尿病を予防するために重要な課題となっている。腸管インクレチンホルモンであるgastric inhibitory...
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StartPage 141
SubjectTerms インクレチン
インスリン
機能性食品成分
腸管内分泌細胞
膵β細胞
Title インクレチンの生理作用と機能性食品成分による調節・模倣
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https://agriknowledge.affrc.go.jp/RN/2030947286
Volume 76
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