TMEM147: A Promising Cancer Biomarker Associated with Immune Cell Infiltration and Prognosis in LIHCInsights from a Comprehensive Pan-Cancer Genomic Analysis

Previous studies have demonstrated the regulatory roles of Transmembrane protein 147 (TMEM147) in various diseases, including cancer. However, systematic pan-cancer analyses investigating the role of TMEM147 in diagnosis, prognosis, and immunological prediction are lacking. An analysis of data from...

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Published inACS omega Vol. 9; no. 25; pp. 27137 - 27157
Main Authors Li, Yongqing, Chen, Hanxiang, Zhang, Bingyang, Liu, Junjun, Ma, Jianping, Ma, Wanshan, Lu, Sumei
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 25.06.2024
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Abstract Previous studies have demonstrated the regulatory roles of Transmembrane protein 147 (TMEM147) in various diseases, including cancer. However, systematic pan-cancer analyses investigating the role of TMEM147 in diagnosis, prognosis, and immunological prediction are lacking. An analysis of data from The Cancer Genome Atlas (TCGA) revealed differential TMEM147 expression across various types of cancer as well as within immune and molecular cancer subtypes. Moreover, high TMEM147 expression was associated with poor disease-specific survival (DSS), overall survival (OS), and progression-free interval (PFI) across cancers, suggesting its potential as a prognostic biomarker. Our study further revealed a significant correlation between TMEM147 expression and T helper cell and Tcm cell infiltration in most cancer types. In the case of liver hepatocellular carcinoma (LIHC), the effect of TMEM147 on prognosis varied among different clinical subtypes. Additionally, functional enrichment analysis revealed an association between TMEM147 and metabolic pathways. Finally, experiments on the MIHA cell line and four LIHC cell lines confirmed the role of TMEM147 in promoting liver cancer cell proliferation, further confirming the clinical value of TMEM147 in liver cancer diagnosis. Our findings suggest that TMEM147 may serve as a diagnostic and prognostic biomarker across cancers while also playing a significant role in LIHC.
AbstractList Previous studies have demonstrated the regulatory roles of Transmembrane protein 147 (TMEM147) in various diseases, including cancer. However, systematic pan-cancer analyses investigating the role of TMEM147 in diagnosis, prognosis, and immunological prediction are lacking. An analysis of data from The Cancer Genome Atlas (TCGA) revealed differential TMEM147 expression across various types of cancer as well as within immune and molecular cancer subtypes. Moreover, high TMEM147 expression was associated with poor disease-specific survival (DSS), overall survival (OS), and progression-free interval (PFI) across cancers, suggesting its potential as a prognostic biomarker. Our study further revealed a significant correlation between TMEM147 expression and T helper cell and Tcm cell infiltration in most cancer types. In the case of liver hepatocellular carcinoma (LIHC), the effect of TMEM147 on prognosis varied among different clinical subtypes. Additionally, functional enrichment analysis revealed an association between TMEM147 and metabolic pathways. Finally, experiments on the MIHA cell line and four LIHC cell lines confirmed the role of TMEM147 in promoting liver cancer cell proliferation, further confirming the clinical value of TMEM147 in liver cancer diagnosis. Our findings suggest that TMEM147 may serve as a diagnostic and prognostic biomarker across cancers while also playing a significant role in LIHC.
Previous studies have demonstrated the regulatory roles of Transmembrane protein 147 (TMEM147) in various diseases, including cancer. However, systematic pan-cancer analyses investigating the role of TMEM147 in diagnosis, prognosis, and immunological prediction are lacking. An analysis of data from The Cancer Genome Atlas (TCGA) revealed differential TMEM147 expression across various types of cancer as well as within immune and molecular cancer subtypes. Moreover, high TMEM147 expression was associated with poor disease-specific survival (DSS), overall survival (OS), and progression-free interval (PFI) across cancers, suggesting its potential as a prognostic biomarker. Our study further revealed a significant correlation between TMEM147 expression and T helper cell and Tcm cell infiltration in most cancer types. In the case of liver hepatocellular carcinoma (LIHC), the effect of TMEM147 on prognosis varied among different clinical subtypes. Additionally, functional enrichment analysis revealed an association between TMEM147 and metabolic pathways. Finally, experiments on the MIHA cell line and four LIHC cell lines confirmed the role of TMEM147 in promoting liver cancer cell proliferation, further confirming the clinical value of TMEM147 in liver cancer diagnosis. Our findings suggest that TMEM147 may serve as a diagnostic and prognostic biomarker across cancers while also playing a significant role in LIHC.Previous studies have demonstrated the regulatory roles of Transmembrane protein 147 (TMEM147) in various diseases, including cancer. However, systematic pan-cancer analyses investigating the role of TMEM147 in diagnosis, prognosis, and immunological prediction are lacking. An analysis of data from The Cancer Genome Atlas (TCGA) revealed differential TMEM147 expression across various types of cancer as well as within immune and molecular cancer subtypes. Moreover, high TMEM147 expression was associated with poor disease-specific survival (DSS), overall survival (OS), and progression-free interval (PFI) across cancers, suggesting its potential as a prognostic biomarker. Our study further revealed a significant correlation between TMEM147 expression and T helper cell and Tcm cell infiltration in most cancer types. In the case of liver hepatocellular carcinoma (LIHC), the effect of TMEM147 on prognosis varied among different clinical subtypes. Additionally, functional enrichment analysis revealed an association between TMEM147 and metabolic pathways. Finally, experiments on the MIHA cell line and four LIHC cell lines confirmed the role of TMEM147 in promoting liver cancer cell proliferation, further confirming the clinical value of TMEM147 in liver cancer diagnosis. Our findings suggest that TMEM147 may serve as a diagnostic and prognostic biomarker across cancers while also playing a significant role in LIHC.
Previous studies have demonstrated the regulatory roles of Transmembrane protein 147 (TMEM147) in various diseases, including cancer. However, systematic pan-cancer analyses investigating the role of TMEM147 in diagnosis, prognosis, and immunological prediction are lacking. An analysis of data from The Cancer Genome Atlas (TCGA) revealed differential TMEM147 expression across various types of cancer as well as within immune and molecular cancer subtypes. Moreover, high TMEM147 expression was associated with poor disease-specific survival (DSS), overall survival (OS), and progression-free interval (PFI) across cancers, suggesting its potential as a prognostic biomarker. Our study further revealed a significant correlation between TMEM147 expression and T helper cell and Tcm cell infiltration in most cancer types. In the case of liver hepatocellular carcinoma (LIHC), the effect of TMEM147 on prognosis varied among different clinical subtypes. Additionally, functional enrichment analysis revealed an association between TMEM147 and metabolic pathways. Finally, experiments on the MIHA cell line and four LIHC cell lines confirmed the role of TMEM147 in promoting liver cancer cell proliferation, further confirming the clinical value of TMEM147 in liver cancer diagnosis. Our findings suggest that TMEM147 may serve as a diagnostic and prognostic biomarker across cancers while also playing a significant role in LIHC.
Author Ma, Wanshan
Lu, Sumei
Chen, Hanxiang
Ma, Jianping
Li, Yongqing
Zhang, Bingyang
Liu, Junjun
AuthorAffiliation The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
Department of Clinical Laboratory Medicine
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Cites_doi 10.1038/nrgastro.2017.119
10.1002/jcp.27751
10.1038/ncomms7354
10.1371/journal.pone.0168907
10.3892/mmr.2019.10295
10.1016/j.immuni.2013.10.003
10.1016/j.acthis.2011.12.006
10.3389/fcell.2023.1187989
10.1074/jbc.M110.132548
10.1016/j.ajhg.2022.08.008
10.1080/10799893.2020.1813761
10.1056/NEJMra1713263
10.1016/j.cell.2018.02.052
10.3389/fgene.2022.937300
10.1016/S0140-6736(22)01200-4
10.1016/j.canlet.2015.07.018
10.1186/s13071-017-2353-8
10.1242/jcs.245357
10.1038/s41419-021-04369-1
10.1016/j.semcancer.2019.08.018
10.1016/j.jcmgh.2017.05.004
10.1089/omi.2011.0118
10.3389/fphar.2018.01345
10.1007/s00018-021-04034-y
10.1016/j.jhep.2019.06.001
10.1038/s41575-019-0217-8
10.1038/516S1a
10.1002/advs.202101230
10.1038/s41467-019-14050-z
10.3748/wjg.v20.i36.12945
10.3322/caac.21654
10.1007/s13277-015-4014-x
10.1186/1471-2105-14-7
10.1038/nbt.3772
10.1002/art.41182
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References ref9/cit9
ref6/cit6
ref3/cit3
ref27/cit27
ref18/cit18
ref11/cit11
ref25/cit25
ref16/cit16
ref29/cit29
ref32/cit32
ref23/cit23
ref8/cit8
ref5/cit5
ref31/cit31
ref2/cit2
ref34/cit34
ref28/cit28
ref20/cit20
ref17/cit17
ref10/cit10
ref26/cit26
ref35/cit35
ref19/cit19
ref21/cit21
ref12/cit12
ref15/cit15
Liu J. (ref14/cit14) 2018; 173
ref22/cit22
ref13/cit13
ref33/cit33
ref4/cit4
ref30/cit30
ref1/cit1
ref24/cit24
ref7/cit7
References_xml – ident: ref34/cit34
  doi: 10.1038/nrgastro.2017.119
– ident: ref4/cit4
  doi: 10.1002/jcp.27751
– ident: ref31/cit31
  doi: 10.1038/ncomms7354
– ident: ref33/cit33
  doi: 10.1371/journal.pone.0168907
– ident: ref11/cit11
  doi: 10.3892/mmr.2019.10295
– ident: ref15/cit15
  doi: 10.1016/j.immuni.2013.10.003
– ident: ref5/cit5
  doi: 10.1016/j.acthis.2011.12.006
– ident: ref30/cit30
  doi: 10.3389/fcell.2023.1187989
– ident: ref7/cit7
  doi: 10.1074/jbc.M110.132548
– ident: ref6/cit6
  doi: 10.1016/j.ajhg.2022.08.008
– ident: ref19/cit19
  doi: 10.1080/10799893.2020.1813761
– ident: ref26/cit26
  doi: 10.1056/NEJMra1713263
– volume: 173
  start-page: 400
  issue: 2
  year: 2018
  ident: ref14/cit14
  publication-title: Cell
  doi: 10.1016/j.cell.2018.02.052
  contributor:
    fullname: Liu J.
– ident: ref2/cit2
  doi: 10.3389/fgene.2022.937300
– ident: ref29/cit29
  doi: 10.1016/S0140-6736(22)01200-4
– ident: ref25/cit25
  doi: 10.1016/j.canlet.2015.07.018
– ident: ref8/cit8
  doi: 10.1186/s13071-017-2353-8
– ident: ref9/cit9
  doi: 10.1242/jcs.245357
– ident: ref20/cit20
  doi: 10.1038/s41419-021-04369-1
– ident: ref1/cit1
  doi: 10.1016/j.semcancer.2019.08.018
– ident: ref35/cit35
  doi: 10.1016/j.jcmgh.2017.05.004
– ident: ref13/cit13
  doi: 10.1089/omi.2011.0118
– ident: ref21/cit21
  doi: 10.3389/fphar.2018.01345
– ident: ref18/cit18
  doi: 10.1007/s00018-021-04034-y
– ident: ref23/cit23
  doi: 10.1016/j.jhep.2019.06.001
– ident: ref32/cit32
  doi: 10.1038/s41575-019-0217-8
– ident: ref28/cit28
  doi: 10.1038/516S1a
– ident: ref24/cit24
  doi: 10.1002/advs.202101230
– ident: ref22/cit22
  doi: 10.1038/s41467-019-14050-z
– ident: ref27/cit27
  doi: 10.3748/wjg.v20.i36.12945
– ident: ref17/cit17
  doi: 10.3322/caac.21654
– ident: ref3/cit3
  doi: 10.1007/s13277-015-4014-x
– ident: ref16/cit16
  doi: 10.1186/1471-2105-14-7
– ident: ref12/cit12
  doi: 10.1038/nbt.3772
– ident: ref10/cit10
  doi: 10.1002/art.41182
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Snippet Previous studies have demonstrated the regulatory roles of Transmembrane protein 147 (TMEM147) in various diseases, including cancer. However, systematic...
Previous studies have demonstrated the regulatory roles of Transmembrane protein 147 (TMEM147) in various diseases, including cancer. However, systematic...
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Title TMEM147: A Promising Cancer Biomarker Associated with Immune Cell Infiltration and Prognosis in LIHCInsights from a Comprehensive Pan-Cancer Genomic Analysis
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