Boronate Affinity-Based Electrochemical Aptasensor for Point-of-Care Glycoprotein Detection

• Published in: Analytical chemistry (Washington) Vol. 94; no. 28; pp. 10206 - 10212
• Main Authors: Hu, Qiong, Hu, Shuhan, Li, Shiqi, Liu, Sijie, Liang, Yiyi, Cao, Xiaojing, Luo, Yilin, Xu, Wanjing, Wang, Haocheng, Wan, Jianwen, Feng, Wenxing, Niu, Li
• Format: Journal Article
• Language: English
• Published: Washington American Chemical Society 19.07.2022
• Subjects: Affinity; Analytical chemistry; Aptamers; aptasensors; blood serum; Chains; Chemistry; detection limit; Diagnosis; early diagnosis; Electrochemistry; ferrocenes; Glycoproteins; Nucleic acids; oligonucleotides; Oligosaccharides; phenylboronic acids; point-of-care systems; Screening; Tags; Tumors; α-Fetoprotein

As a class of oligosaccharide chain-containing proteins, glycoproteins are of great value in screening and early diagnosis of malignant tumors and other major diseases. Herein, we report a universal boronate affinity-based electrochemical aptasensor for point-of-care glycoprotein detection. Aptasens...