Quantifying Nanoparticle Adhesion Mediated by Specific Molecular Interactions

• Published in: Langmuir Vol. 24; no. 16; pp. 8821 - 8832
• Main Authors: Haun, Jered B, Hammer, Daniel A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 19.08.2008
• Subjects: Adhesiveness; Biological Interfaces: Biocolloids, Biomolecular and Biomimetic Materials; Chemistry; Colloidal state and disperse state; Computer Simulation; Exact sciences and technology; General and physical chemistry; Humans; Intercellular Adhesion Molecule-1 - chemistry; Ligands; Monte Carlo Method; Nanoparticles - chemistry; Particle Size; Physical and chemical studies. Granulometry. Electrokinetic phenomena; Surface physical chemistry; Shear; Nanoparticle; Molecular interaction; Selectivity; Potential; Density; Dynamic conditions; Avidin; Mechanism; Design; Particle; Dynamics; Efficiency; Dissociation; Rate constant; Binding; Drug; Flow rate; Hydrodynamic force; Antibody; Biotin; Adhesion; Complexes; Chemistry; Models; Kinetics; Transport

Receptor-mediated targeting of nanometric contrast agents or drug carriers holds great potential for treating cardiovascular and vascular-associated diseases. However, predicting the ability of these vectors to adhere to diseased cells under dynamic conditions is complex due to the interplay of tran...