Electrospun Bio-Nanocomposite Scaffolds for Bone Tissue Engineering by Cellulose Nanocrystals Reinforcing Maleic Anhydride Grafted PLA

Electrospun fibrous bio-nanocomposite scaffolds reinforced with cellulose nanocrystals (CNCs) were fabricated by using maleic anhydride (MAH) grafted poly(lactic acid) (PLA) as matrix with improved interfacial adhesion between the two components. Morphological, thermal, mechanical, and in vitro degr...

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Published inACS applied materials & interfaces Vol. 5; no. 9; pp. 3847 - 3854
Main Authors Zhou, Chengjun, Shi, Qingfeng, Guo, Weihong, Terrell, Lekeith, Qureshi, Ammar T, Hayes, Daniel J, Wu, Qinglin
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 08.05.2013
Subjects
Cell Survival - physiology
Cells, Cultured
Cellulose - chemistry
Electrochemical Techniques - methods
Humans
Lactic Acid - chemistry
Maleic Anhydrides - chemistry
Materials Testing
Mesenchymal Stromal Cells - cytology
Nanocomposites - chemistry
Nanocomposites - ultrastructure
Nanoparticles - chemistry
Nanotechnology - methods
Polyesters
Polymers - chemistry
Temperature
Tissue Engineering
Tissue Scaffolds - chemistry
cellulose nanocrystals (CNCs)
scaffolds
electrospinning
nanocomposites
modification
poly(lactic acid)
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Summary:Electrospun fibrous bio-nanocomposite scaffolds reinforced with cellulose nanocrystals (CNCs) were fabricated by using maleic anhydride (MAH) grafted poly(lactic acid) (PLA) as matrix with improved interfacial adhesion between the two components. Morphological, thermal, mechanical, and in vitro degradation properties as well as basic cytocompatibility using human adult adipose derived mesenchymal stem cells (hASCs) of MAH grafted PLA/CNC (i.e., MPLA/CNC) scaffolds were characterized. Morphological investigation indicated that the diameter and polydispersity of electrospun MPLA/CNC nanofibers were reduced with the increased CNC content. The addition of CNCs improved both the thermal stability and mechanical properties of MPLA/CNC composites. The MPLA/CNC scaffolds at the 5 wt % CNC loading level showed not only superior tensile strength (more than 10 MPa), but also improved stability during in vitro degradation compared with the MPLA and PLA/CNC counterparts. Moreover, the fibrous MPLA/CNC composite scaffolds were non-toxic to hASCs and capable of supporting cell proliferation. This study demonstrates that fibrous MPLA/CNC bio-nanocomposite scaffolds are biodegradable, cytocompatible, and possess useful mechanical properties for bone tissue engineering.
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ISSN:1944-8244
1944-8252
DOI:10.1021/am4005072