Efficient Synthesis of a Trisubstituted 1,6-Naphthyridone from Acetonedicarboxylate and Regioselective Suzuki Arylation

An efficient five-step synthesis of 1,6-naphthyridone 3b, a p38 mitogen-activated protein (MAP) kinase inhibitor intermediate, in 32% overall yield starting from acetonedicarboxylate (ADC) is described. The synthesis began with a selective monoamidation of ADC dimethyl ester enolate 9. A novel conco...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 70; no. 25; pp. 10342 - 10347
Main Authors Chung, John Y. L, Cai, Chaoxian, McWilliams, J. Christopher, Reamer, Robert A, Dormer, Peter G, Cvetovich, Raymond J
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 09.12.2005
Amer Chemical Soc
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