Next-Generation Metal Anticancer Complexes: Multitargeting via Redox Modulation

• Published in: Inorganic chemistry Vol. 52; no. 21; pp. 12276 - 12291
• Main Authors: Romero-Canelón, Isolda, Sadler, Peter J.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.11.2013
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Cell Line, Tumor; Drug Screening Assays, Antitumor - methods; Humans; Iridium - chemistry; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Osmium - chemistry; Oxidation-Reduction; Ruthenium - chemistry

Platinum complexes are widely used anticancer drugs. New generations of metal chemotherapeutics offer the prospect of combating platinum resistance and expanding the range of treatable cancers. Such new complexes might be effective if they form distinctly different lesions on DNA. In this Forum Arti...