Mild and Practical Method for the α-Arylation of Nitriles with Heteroaryl Halides
A mild and transition-metal-free method for the α-arylation of aliphatic nitriles with activated heteroaryl halides was developed using NaHMDS or KHMDS as base at ambient temperature. The key to the success of this method is generation of the nitrile anion in the presence of the heteroaryl halide. T...
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Published in | Journal of organic chemistry Vol. 70; no. 24; pp. 10186 - 10189 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
25.11.2005
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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