Assessing the Risk of pH-Dependent Absorption for New Molecular Entities: A Novel in Vitro Dissolution Test, Physicochemical Analysis, and Risk Assessment Strategy - Mathias, Neil R; Xu, Yan; Patel, Dhaval; Grass, Michael; Caldwell, Brett; Jager, Casey; Mullin, Jim; Hansen, Luke; Crison, John; Saari, Amy; Gesenberg, Christoph; Morrison, John; et al. (Molecular pharmaceutics, 2013)
Keywords: Absorption; Achlorhydria - metabolism; Humans; Hydrogen-Ion Concentration; Models, Theoretical; Risk Assessment; risk assessment; precipitation; pH-effect; physicochemical properties; dissolution; in vitro−in vivo correlation; supersaturation; achlorhydria