Synthesis of 1-tert-Butyl-4-chloropiperidine:  Generation of an N-tert-Butyl Group by the Reaction of a Dimethyliminium Salt with Methylmagnesium Chloride

Two efficient routes to 1-tert-butyl-4-chloropiperidine are described. In the first route, the key thionyl chloride mediated chlorination reaction features the use of tetrabutylammonium chloride as an additive that effectively suppresses the formation of an elimination-derived side product. In the s...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 70; no. 5; pp. 1930 - 1933
Main Authors Amato, Joseph S, Chung, John Y. L, Cvetovich, Raymond J, Gong, Xiaoyi, McLaughlin, Mark, Reamer, Robert A
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 04.03.2005
Amer Chemical Soc
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