Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents

Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding...

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Published inInorganic chemistry Vol. 53; no. 2; pp. 727 - 736
Main Authors Almodares, Zahra, Lucas, Stephanie J, Crossley, Benjamin D, Basri, Aida M, Pask, Christopher M, Hebden, Andrew J, Phillips, Roger M, McGowan, Patrick C
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 21.01.2014
Subjects
Amides - chemistry
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Hypoxia
HT29 Cells
Humans
Inhibitory Concentration 50
Iridium - chemistry
MCF-7 Cells
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Picolinic Acids - chemistry
Rhodium - chemistry
Ruthenium - chemistry
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Abstract Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.
AbstractList Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.
Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.
Author Crossley, Benjamin D
McGowan, Patrick C
Phillips, Roger M
Basri, Aida M
Lucas, Stephanie J
Almodares, Zahra
Hebden, Andrew J
Pask, Christopher M
AuthorAffiliation University of Leeds
The Institute of Cancer Therapeutics
School of Chemistry
University of Bradford
AuthorAffiliation_xml – name: The Institute of Cancer Therapeutics
– name: University of Leeds
– name: University of Bradford
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  givenname: Zahra
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  surname: Lucas
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  givenname: Benjamin D
  surname: Crossley
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  givenname: Aida M
  surname: Basri
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  givenname: Christopher M
  surname: Pask
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– sequence: 6
  givenname: Andrew J
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Snippet Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The...
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SubjectTerms Amides - chemistry
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Hypoxia
HT29 Cells
Humans
Inhibitory Concentration 50
Iridium - chemistry
MCF-7 Cells
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Picolinic Acids - chemistry
Rhodium - chemistry
Ruthenium - chemistry
Title Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents
URI http://dx.doi.org/10.1021/ic401529u
https://www.ncbi.nlm.nih.gov/pubmed/24397747
https://www.proquest.com/docview/1491063764
Volume 53
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