Cytotoxic and Antibacterial Preussomerins from the Mangrove Endophytic Fungus Lasiodiplodia theobromae ZJ-HQ1

• Published in: Journal of natural products (Washington, D.C.) Vol. 79; no. 9; pp. 2397 - 2402
• Main Authors: Chen, Senhua, Chen, Dongni, Cai, Runlin, Cui, Hui, Long, Yuhua, Lu, Yongjun, Li, Chunyuan, She, Zhigang
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 23.09.2016; Amer Chemical Soc
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Ascomycota - chemistry; Chemistry, Medicinal; copper; Crystallography, X-Ray; cytotoxicity; Drug Screening Assays, Antitumor; endophytes; Endophytes - chemistry; fungi; HeLa Cells; Hep G2 Cells; Humans; inhibitory concentration 50; Lasiodiplodia theobromae; Life Sciences & Biomedicine; MCF-7 Cells; minimum inhibitory concentration; Mitosporic Fungi - chemistry; Molecular Structure; neoplasms; Nuclear Magnetic Resonance, Biomolecular; Pharmacology & Pharmacy; Plant Sciences; Science & Technology; spectral analysis; Staphylococcus aureus; Staphylococcus aureus - drug effects; X-ray diffraction; METABOLITES; ABSOLUTE-CONFIGURATION; GLUCOSIDASE INHIBITORY-ACTIVITY; SESTERTERPENOIDS; PREUSSIA-ISOMERA; EDENIA-GOMEZPOMPAE; IFO 31059

Two new chlorinated preussomerins, chloropreussomerins A and B (1 and 2), together with nine known preussomerin analogues, 3–11, were obtained from the endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. Their structures were elucidated by a combination of spectroscopic analyses. The absolute configu...