Specific dopamine D-1 and DA1 properties of 4-(mono- and -dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline and its tetrahydrothieno[2,3c]pyridine analog

• Published in: Journal of medicinal chemistry Vol. 30; no. 8; pp. 1454 - 1458
• Main Authors: Riggs, Robert M, Nichols, David E, Foreman, Mark M, Truex, Lewis L, Glock, Dana, Kohli, Jai D
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.08.1987
• Subjects: Adenylyl Cyclases - metabolism; Animals; Chemical Phenomena; Chemistry; Dogs; Dopamine - pharmacology; Exact sciences and technology; Heterocyclic compounds; Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms; Isoquinolines - pharmacology; Male; Organic chemistry; Preparations and properties; Pyridines - pharmacology; Rats; Receptors, Dopamine - drug effects; Receptors, Dopamine - physiology; Receptors, Dopamine D1; Receptors, Dopamine D2; Renal Artery - physiology; Retina - enzymology; Structure-Activity Relationship; Thiophenes - pharmacology; Vasodilation - drug effects; Sulfur nitrogen heterocycle; Agonist; Nitrogen heterocycle; Bicyclic compound; Phenols; Antidepressant agent; Benzenic compound; Aromatic compound; Diphenols; Biological activity; Dopaminergic receptor D1

The title compounds were prepared and examined to elucidate further the structure-activity relationships of dopamine agonists related to nomifensine. Two of the compounds, 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline and 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydrothieno[2,3-c]pyridine, have...