Regulatory Role of Ubiquitin in Eukaryotic DNA Translesion Synthesis

• Published in: Biochemistry (Easton) Vol. 52; no. 19; pp. 3217 - 3228
• Main Authors: Yang, Kun, Weinacht, Christopher P, Zhuang, Zhihao
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14.05.2013
• Subjects: Amino Acid Sequence; Animals; cell membranes; chromatin; DNA; DNA Damage; DNA Repair - physiology; DNA replication; DNA-Directed DNA Polymerase - chemistry; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; enzymatic treatment; eukaryotic cells; genome; Humans; innate immunity; Models, Biological; Models, Molecular; Molecular Sequence Data; nucleotides; physiological transport; proliferating cell nuclear antigen; Proliferating Cell Nuclear Antigen - chemistry; Proliferating Cell Nuclear Antigen - metabolism; Protein Conformation; protein degradation; Protein Processing, Post-Translational; researchers; Sequence Homology, Amino Acid; therapeutics; ubiquitin; Ubiquitin - metabolism; Ubiquitination; X-radiation; X-ray diffraction

Although often associated with proteasome-mediated protein degradation, ubiquitin plays essential nondegradative roles in a myriad of cellular processes, including chromatin dynamics, membrane trafficking, innate immunity, and DNA damage response. The recent progress in understanding DNA translesion...