Use of Artificial Stomach−Duodenum Model for Investigation of Dosing Fluid Effect on Clinical Trial Variability - Polster, Christopher S; Atassi, Faraj; Wu, Sy-Juen; Sperry, David C (Molecular pharmaceutics, 2010)
Keywords: Administration, Oral; Analysis of Variance; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacokinetics; Body Fluids - metabolism; Capsules - administration & dosage; Chemistry, Pharmaceutical - methods; Clinical Trials as Topic; Duodenum - metabolism; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Models, Biological; Pharmacokinetics; Stomach - metabolism; dosing fluid selection; GI simulation; Artificial stomach duodenum; clinical trial variability; variability mitigation; oncology; gastric pH effect