Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine

• Published in: Molecular pharmaceutics Vol. 11; no. 10; pp. 3547 - 3555
• Main Authors: Drozdzik, Marek, Gröer, Christian, Penski, Jette, Lapczuk, Joanna, Ostrowski, Marek, Lai, Yurong, Prasad, Bhagwat, Unadkat, Jashvant D, Siegmund, Werner, Oswald, Stefan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.10.2014
• Subjects: Adult; Colon - metabolism; Duodenum - metabolism; Female; Humans; Ileum - metabolism; In Vitro Techniques; Intestinal Absorption; Intestine, Small - metabolism; Intestines - metabolism; Jejunum - metabolism; Male; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; Middle Aged; Multidrug Resistance-Associated Proteins - genetics; Multidrug Resistance-Associated Proteins - metabolism; Organic Cation Transport Proteins - genetics; Organic Cation Transport Proteins - metabolism; RNA, Messenger - metabolism; Symporters - genetics; Symporters - metabolism; Young Adult; drug transporters; intestine; protein abundance; human; gene expression

Intestinal transporters are crucial determinants in the oral absorption of many drugs. We therefore studied the mRNA expression (N = 33) and absolute protein content (N = 10) of clinically relevant transporters in healthy epithelium of the duodenum, the proximal and distal jejunum and ileum, and the...