Diterpenoids and Their Glycosides from the Stems of Tinospora crispa with Beta-Cell Protective Activity

• Published in: Journal of natural products (Washington, D.C.) Vol. 86; no. 6; pp. 1437 - 1448
• Main Authors: Lam, Sio-Hong, Liu, Hui-Kang, Chung, Shih-Yuan, Chang, Jia-Ling, Hong, Mao-Xuan, Kuo, Sheng-Chu, Liaw, Chih-Chuang
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 23.06.2023; Amer Chemical Soc
• Subjects: Chemistry, Medicinal; Dexamethasone; Diterpenes - pharmacology; diterpenoids; dose response; glycosides; Glycosides - chemistry; Glycosides - pharmacology; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Plant Sciences; protective effect; Science & Technology; spectroscopy; sugars; Tinospora - chemistry; Tinospora crispa; TUBERCULATA BEUMEE; IN-VITRO; DEXAMETHASONE; GLUCOCORTICOIDS; INHIBITION; TRANSCRIPTION; RISK; INSULIN-SECRETING CELLS; BORAPETOSIDE; CONSTITUENTS

Seven previously undescribed diterpenoids, tinocrisposides A–D (1–4) and borapetic acids A (5), B (6), and C (7), together with 16 known compounds, were isolated from the stem of Tinospora crispa (Menispermaceae). The structures of the new isolates were elucidated by spectroscopic and chemical metho...