An Efficient Chemoenzymatic Approach to (S)-γ-Fluoroleucine Ethyl Ester
An asymmetric synthesis of (S)-γ-fluoroleucine ethyl ester 1 is described. The key transformation involves a lipase-catalyzed dynamic ring-opening of 2-(3-butenyl)azlactone 7b with EtOH to give amide ester (S)-6b in 84% enantiomeric excess. Removal of the N-pentenoyl group with N,N‘-dibromodimethylh...
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Published in | Journal of organic chemistry Vol. 70; no. 6; pp. 2372 - 2375 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
18.03.2005
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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