Rules for Anionic and Radical Ring Closure of Alkynes

• Published in: Journal of the American Chemical Society Vol. 133; no. 32; pp. 12608 - 12623
• Main Authors: Alabugin, Igor V, Gilmore, Kerry, Manoharan, Mariappan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.08.2011

This work reexamined the stereoelectronic basis for the “favored attack trajectories” regarding the nucleophilic and radical cyclizations of alkynes. In contrast to the original Baldwin rules, the acute attack angle of a nucleophile leading to the proposed endo-dig preference for the formation of sm...