Spontaneous Intermolecular Amide Bond Formation between Side Chains for Irreversible Peptide Targeting

• Published in: Journal of the American Chemical Society Vol. 132; no. 13; pp. 4526 - 4527
• Main Authors: Zakeri, Bijan, Howarth, Mark
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.04.2010
• Subjects: Amides - chemistry; HeLa Cells; Humans; Models, Molecular; Molecular Structure; Peptides - chemistry; Time Factors

Peptides and synthetic peptide-like molecules are powerful tools for analysis and control of biological function. One major limitation of peptides is the instability of their interactions with biomolecules, because of the limited accessible surface area for noncovalent interactions and the intrinsic...