Contrasting Reactivity and Cancer Cell Cytotoxicity of Isoelectronic Organometallic Iridium(III) Complexes

• Published in: Inorganic chemistry Vol. 50; no. 12; pp. 5777 - 5783
• Main Authors: Liu, Zhe, Salassa, Luca, Habtemariam, Abraha, Pizarro, Ana M, Clarkson, Guy J, Sadler, Peter J
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 20.06.2011
• Subjects: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Iridium - chemistry; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Quantum Theory; Stereoisomerism; Structure-Activity Relationship

Replacing the N,N-chelating ligand 2,2′-bipyridine (bpy) in the IrIII pentamethylcyclopentadienyl (Cp*) complex [(η5-C5Me5)Ir(bpy)Cl]+ (1) with the C,N-chelating ligand 2-phenylpyridine (phpy) to give [(η5-C5Me5)Ir(phpy)Cl] (2) switches on cytotoxicity toward A2780 human ovarian cancer cells (IC50 v...