Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies

An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum, is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania (Viannia) panamensis. A topical formulation containing 0....

Full description

Saved in:
Bibliographic Details
Published inAntimicrobial agents and chemotherapy Vol. 59; no. 9; pp. 5804 - 5813
Main Authors Montoya, Andrés, Daza, Alejandro, Muñoz, Diana, Ríos, Karina, Taylor, Viviana, Cedeño, David, Vélez, Iván D, Echeverri, Fernando, Robledo, Sara M
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.09.2015
Subjects
Animals
Anthracenes
Cell Line
Cricetinae
Experimental Therapeutics
Humans
Leishmania - drug effects
Leishmania - pathogenicity
Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous - drug therapy
Leishmaniasis, Cutaneous - therapy
Perylene
Perylene - analogs & derivatives
Perylene - therapeutic use
Photochemotherapy
Photochemotherapy - methods
Photosensitizing Agents
Photosensitizing Agents - therapeutic use
U937 Cells
Wound Healing - drug effects
Online AccessGet full text

Cover

Abstract An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum, is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania (Viannia) panamensis. A topical formulation containing 0.5% hypericin was developed and assayed in vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effect in vitro against L. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing of L. panamensis-induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm(2), 15 min), twice a week for 3 weeks.
AbstractList An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum , is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania ( Viannia ) panamensis . A topical formulation containing 0.5% hypericin was developed and assayed in vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effect in vitro against L. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing of L. panamensis -induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm 2 , 15 min), twice a week for 3 weeks.
An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum, is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania (Viannia) panamensis. A topical formulation containing 0.5% hypericin was developed and assayed in vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effect in vitro against L. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing of L. panamensis-induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm(2), 15 min), twice a week for 3 weeks.
An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum, is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania (Viannia) panamensis. A topical formulation containing 0.5% hypericin was developed and assayed in vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effect in vitro against L. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing of L. panamensis-induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm2, 15 min), twice a week for 3 weeks.
ABSTRACT An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum , is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania ( Viannia ) panamensis . A topical formulation containing 0.5% hypericin was developed and assayed in vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effect in vitro against L. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing of L. panamensis -induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm 2 , 15 min), twice a week for 3 weeks.
Author Echeverri, Fernando
Daza, Alejandro
Taylor, Viviana
Muñoz, Diana
Cedeño, David
Vélez, Iván D
Ríos, Karina
Robledo, Sara M
Montoya, Andrés
Author_xml – sequence: 1
  givenname: Andrés
  surname: Montoya
  fullname: Montoya, Andrés
  organization: PECET-Medical Research institute, School of Medicine, University of Antioquia, Medellín, Colombia
– sequence: 2
  givenname: Alejandro
  surname: Daza
  fullname: Daza, Alejandro
  organization: PECET-Medical Research institute, School of Medicine, University of Antioquia, Medellín, Colombia
– sequence: 3
  givenname: Diana
  surname: Muñoz
  fullname: Muñoz, Diana
  organization: PECET-Medical Research institute, School of Medicine, University of Antioquia, Medellín, Colombia
– sequence: 4
  givenname: Karina
  surname: Ríos
  fullname: Ríos, Karina
  organization: PECET-Medical Research institute, School of Medicine, University of Antioquia, Medellín, Colombia
– sequence: 5
  givenname: Viviana
  surname: Taylor
  fullname: Taylor, Viviana
  organization: PECET-Medical Research institute, School of Medicine, University of Antioquia, Medellín, Colombia
– sequence: 6
  givenname: David
  surname: Cedeño
  fullname: Cedeño, David
  organization: Department of Chemistry, Illinois State University, Normal, Illinois, USA
– sequence: 7
  givenname: Iván D
  surname: Vélez
  fullname: Vélez, Iván D
  organization: PECET-Medical Research institute, School of Medicine, University of Antioquia, Medellín, Colombia
– sequence: 8
  givenname: Fernando
  surname: Echeverri
  fullname: Echeverri, Fernando
  organization: QOPN-Institute of Chemistry, School of Exact and Natural Sciences, University of Antioquia, Medellín, Colombia
– sequence: 9
  givenname: Sara M
  surname: Robledo
  fullname: Robledo, Sara M
  email: sara.robledo@udea.edu.co
  organization: PECET-Medical Research institute, School of Medicine, University of Antioquia, Medellín, Colombia sara.robledo@udea.edu.co
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26169411$$D View this record in MEDLINE/PubMed
BookMark eNp1kU1v1DAQhi1URLeFG2fkI0ik2IntxBek1fIpVeICZ2uSTIirxA62s9X-C34yLikVHJAsjcbz-hnPvBfkzHmHhDzn7Irzsnmz3x-uGJNCFlw-IjvOdFMoqdUZ2TGmVCEaJs7JRYw3LOdSsyfkvFRcacH5jvx8h0ec_DKjS9QPFKjz-YIOPszrBMl6R29tGul4WjDYzjqaPE0BIdFuTeDQr5FOaOM4g7MQbaQtROxpfriMPvn-5GC2HU0jBlhONBPyOdoUPAXXb8nR05jW3mJ8Sh4PMEV8dh8vybcP778ePhXXXz5-PuyvC6galopOs4H3bQNNCYwrHJSuJddYo5KNgJqJroK-B6G7UrVclUPTagGoFUhZDqq6JG837rK2M_Zdnj_AZJZgZwgn48GafyvOjua7Pxohq0ayMgNe3gOC_7FiTGa2scNp2nZieP5DJWpV30lfb9Iu-BgDDg9tODN3JppsovltouEyy19tcohzaW78GlzexP-0L_4e4wH8x-HqF6tiqjg
CitedBy_id crossref_primary_10_3389_fchem_2020_623971
crossref_primary_10_1016_j_pdpdt_2023_103641
crossref_primary_10_1016_j_exppara_2018_09_016
crossref_primary_10_3390_bioengineering10010121
crossref_primary_10_1128_AAC_01879_15
crossref_primary_10_1016_j_pdpdt_2021_102609
crossref_primary_10_1016_j_apjtb_2017_05_007
crossref_primary_10_1016_j_indcrop_2020_113053
crossref_primary_10_1016_j_jddst_2022_103605
crossref_primary_10_1016_j_jphotobiol_2021_112236
crossref_primary_10_1016_j_pdpdt_2020_101769
crossref_primary_10_1002_ptr_8204
crossref_primary_10_1177_15347346231212332
crossref_primary_10_1016_j_bioadv_2023_213645
crossref_primary_10_1186_s13071_016_1647_6
crossref_primary_10_1021_acs_jnatprod_6b00740
crossref_primary_10_1016_j_phymed_2023_154654
crossref_primary_10_2174_1381612826666201109111802
crossref_primary_10_2217_fmb_2018_0304
crossref_primary_10_1039_c7pp00458c
crossref_primary_10_3390_plants11192509
crossref_primary_10_2139_ssrn_4064668
crossref_primary_10_1016_j_surfin_2022_102468
crossref_primary_10_1016_j_actatropica_2017_10_008
crossref_primary_10_1016_j_pdpdt_2017_04_009
crossref_primary_10_1016_j_pdpdt_2023_103858
crossref_primary_10_1016_j_actatropica_2021_105988
crossref_primary_10_1093_mmy_myab006
crossref_primary_10_1016_j_pdpdt_2020_101676
crossref_primary_10_1007_s00044_019_02446_x
crossref_primary_10_1080_1040841X_2022_2036100
crossref_primary_10_1016_j_pdpdt_2017_11_017
crossref_primary_10_1016_j_jphotobiol_2018_04_017
crossref_primary_10_1007_s00580_017_2426_2
crossref_primary_10_1016_j_jphotobiol_2017_08_016
crossref_primary_10_1016_j_pdpdt_2022_103111
crossref_primary_10_1016_j_pdpdt_2018_05_005
Cites_doi 10.1111/j.1600-0625.2007.00578.x
10.1111/j.1365-2133.2007.08329.x
10.1016/j.exppara.2009.02.012
10.1016/S0151-9638(13)70138-8
10.1016/j.jphotobiol.2008.01.011
10.1371/journal.pone.0035671
10.1016/j.pdpdt.2009.10.008
10.1038/nprot.2007.30
10.1089/wound.2013.0466
10.1016/j.drup.2006.04.001
10.1021/np400394c
10.1016/j.pdpdt.2007.02.002
10.1111/j.1067-1927.2005.130108.x
10.1111/j.1365-2915.1990.tb00255.x
10.1111/j.1751-1097.1991.tb08468.x
10.1016/j.actatropica.2007.05.005
10.3390/ijerph7124267
10.2174/092986706777935267
10.1016/j.canlet.2005.10.020
10.1371/journal.pone.0009730
10.1111/myc.12099
10.1111/j.1600-0781.2011.00610.x
10.1590/S0120-41572014000400012
10.1002/lsm.22099
10.3892/or.2011.1262
10.3791/3533
10.1016/j.ijpharm.2013.06.067
10.1016/j.juro.2007.12.038
10.1128/AAC.00671-11
10.1007/s12262-012-0447-2
10.1074/jbc.M113.489013
10.1371/journal.pone.0041105
10.1111/j.1067-1927.2004.12406.x
10.1126/science.276.5309.75
10.1001/archderm.139.4.432
10.1128/AAC.04169-14
10.1016/j.exppara.2011.04.009
10.1073/pnas.1324235111
10.1128/AAC.49.4.1652-1655.2005
10.1016/j.phrs.2008.06.004
10.1016/j.actatropica.2011.11.015
10.1111/j.1600-0781.2012.00694.x
10.12659/MSMBR.890337
10.1111/pim.12007
10.1016/j.pdpdt.2012.11.007
10.1016/S0140-6736(05)67700-8
10.1590/S0365-05962011000300012
10.1080/09553008514550211
10.4049/jimmunol.152.3.1265
ContentType Journal Article
Copyright Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Copyright © 2015, American Society for Microbiology. All Rights Reserved. 2015 American Society for Microbiology
Copyright_xml – notice: Copyright © 2015, American Society for Microbiology. All Rights Reserved.
– notice: Copyright © 2015, American Society for Microbiology. All Rights Reserved. 2015 American Society for Microbiology
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
5PM
DOI 10.1128/AAC.00545-15
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic

MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
Pharmacy, Therapeutics, & Pharmacology
DocumentTitleAlternate Hypericin and Phototherapy in Cutaneous Leishmaniasis, Montoya et al
Hypericin and Phototherapy in Cutaneous Leishmaniasis
EISSN 1098-6596
EndPage 5813
ExternalDocumentID 10_1128_AAC_00545_15
00545-15
26169411
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
.55
.GJ
0R~
23M
2WC
39C
3O-
4.4
53G
5GY
5RE
5VS
6J9
ACGFO
ADBBV
AENEX
AGNAY
AGVNZ
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CGR
CS3
CUY
CVF
DIK
E3Z
EBS
ECM
EIF
EJD
F5P
FRP
GX1
H13
HH5
HYE
HZ~
H~9
J5H
K-O
KQ8
L7B
LSO
MVM
NEJ
NPM
O9-
OK1
P2P
RHF
RHI
RNS
RPM
RSF
TR2
UHB
VH1
W2D
W8F
WH7
WHG
WOQ
X7M
X7N
XOL
Y6R
ZGI
ZXP
~A~
-
0R
55
AAPBV
ABFLS
ADACO
BXI
HZ
ZA5
AAYXX
CITATION
7X8
5PM
ID FETCH-LOGICAL-a380t-c90f1db8a82a016ef697519e7e6584a704c3adda49c26b162f8b94ae96a552f63
IEDL.DBID RPM
ISSN 0066-4804
IngestDate Tue Sep 17 21:31:13 EDT 2024
Sat Aug 17 05:48:23 EDT 2024
Thu Sep 12 17:07:47 EDT 2024
Tue Dec 28 13:59:04 EST 2021
Sun Oct 13 09:27:01 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 9
Language English
License Copyright © 2015, American Society for Microbiology. All Rights Reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a380t-c90f1db8a82a016ef697519e7e6584a704c3adda49c26b162f8b94ae96a552f63
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Citation Montoya A, Daza A, Muñoz D, Ríos K, Taylor V, Cedeño D, Vélez ID, Echeverri F, Robledo SM. 2015. Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies. Antimicrob Agents Chemother 59:5804–5813. doi:10.1128/AAC.00545-15.
Present address: Karina Ríos, Faculty of Health, University of Santander, Cucuta, Colombia; Viviana Taylor, Faculty of Health and Faculty of Basic Sciences, University Santiago de Cali, Valle, Colombia; David Cedeño, Millennium Pain Center, Basic Science, Bloomington, Illinois, USA.
PMID 26169411
PQID 1704347672
PQPubID 23479
PageCount 10
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4538502
proquest_miscellaneous_1704347672
crossref_primary_10_1128_AAC_00545_15
asm2_journals_10_1128_AAC_00545_15
pubmed_primary_26169411
PublicationCentury 2000
PublicationDate 2015-09-01
PublicationDateYYYYMMDD 2015-09-01
PublicationDate_xml – month: 09
  year: 2015
  text: 2015-09-01
  day: 01
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: 1752 N St., N.W., Washington, DC
PublicationTitle Antimicrobial agents and chemotherapy
PublicationTitleAbbrev Antimicrob Agents Chemother
PublicationTitleAlternate Antimicrob Agents Chemother
PublicationYear 2015
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References Kim, SW, Zhang, HZ, Guo, L, Kim, JM, Kim, MH (B35) 2012; 7
Basset-Seguin, N (B37) 2013; 140
Oladipupo, SS, Smith, C, Santeford, A, Park, C, Sene, A, Wiley, LA, Osei-Owusu, P, Hsu, J, Zapata, N, Liu, F, Nakamura, R, Lavine, KJ, Blumer, KJ, Choi, K, Apte, RS, Ornitz, DM (B57) 2014; 111
Kashef, N, Borghei, YS, Djavid, GE (B19) 2013; 10
Boiy, R, Roelandts, R, van den Oord, JJ, de Witte, PA (B45) 2008; 158
Varela, M, Muñoz, REDL, Robledo, SM, Kolli, BK, Dutta, S, Chang, KP, Muskus, C (B30) 2009; 122
Robledo, SM, Carrillo, LM, Daza, A, Restrepo, AM, Muñoz, DL, Tobón, J, Murillo, JD, López, A, Ríos, C, Mesa, CV, Upegui, YA, Valencia-Tobón, A, Mondragón-Shem, K, Rodríguez, B, Vélez, ID (B32) 2012; 62
Sayar, H, Gergerlioglu, N, Seringec, N, Ozturk, P, Bulbuloglu, E, Karabay, G (B24) 2014; 20
Liang, CC, Park, AY, Guan, JL (B36) 2007; 2
Boiy, A, Roelandts, R, Roskams, T, de Witte, PA (B44) 2007; 4
Nylén, S, Eidsmo, L (B1) 2012; 34
Pulido, SA, Muñoz, DL, Restrepo, AM, Mesa, CV, Alzate, JF, Vélez, ID, Robledo, SM (B31) 2012; 122
Dai, T, Huang, YY, Hamblin, MR (B11) 2009; 6
Enk, CD, Fritsch, C, Jonas, F, Nasereddin, A, Ingber, A, Jaffe, CL, Ruzicka, T (B14) 2003; 139
Schiavone, BI, Rosato, A, Marilena, M, Gibbons, S, Bombardelli, E, Verotta, L, Franchini, C, Corbo, F (B23) 2013; 76
Peloi, LS, Biondo, CE, Kimura, E, Politi, MJ, Lonardoni, MV, Aristides, SM, Dorea, RC, Hioka, N, Silveira, TG (B16) 2011 Photodynamic therapy for American cutaneous leishmaniasis: the efficacy of methylene blue in hamsters experimentally infected with Leishmania (Leishmania) amazonensis. Exp Parasitol; 128
(B34) 2004
Paz-Cristobal, MP, Royo, D, Rezusta, A, Andrés-Ciriano, E, Alejandre, MC, Meis, JF, Revillo, MJ, Aspiroz, C, Nonell, S, Gilaberte, Y (B20) 2014; 57
Kiesslich, T, Krammer, B, Plaetzer, K (B43) 2006; 13
Moseley, R, Hilton, JR, Waddington, RJ, Harding, KG, Stephens, P, Thomas, DW (B50) 2004; 12
Singla, S, Singla, S, Kumar, A, Singla, M (B58) 2012; 74
Tredget, EB, Demare, J, Chandran, G, Tredget, EE, Yang, L, Ghahary, A (B54) 2005; 13
(B3) 2010; 949
Curnow, SJ, Fairclough, M, Schmutz, C, Kissane, S, Denniston, AK, Nash, K, Buckley, CD, Lord, JM, Salmon, M (B27) 2010; 5
Martin, P (B49) 1997; 276
Almeida, OL, Santos, JB (B4) 2011; 86
Alvar, J, Velez, ID, Bern, C, Herrero, M, Desjeux, P, Cano, P, Jannin, J, den Boer, M (B2) 2012; 7
Pandey, RK, Bellnier, DA, Smith, KM, Dougherty, TJ (B46) 1991; 53
Taylor, VM, Cedeño, DL, Muñoz, DL, Jones, MA, Lash, TD, Young, AM, Constantino, MH, Esposito, N, Vélez, ID, Robledo, SM (B10) 2011; 55
Mohebali, M, Fotouhi, A, Hooshmand, B, Zarei, Z, Akhoundi, B, Rahnema, A, Razaghian, AR, Kabir, MJ, Nadim, A (B8) 2007; 103
Huygens Crnolatac, I, Develter, J, Van Cleynenbreugel, B, Van der Kwast, T, de Witte, PA (B40) 2008; 179
Akilov, OE, Kosaka, S, O'Riordan, K, Hasan, T (B12) 2007; 16
Ben-Hur, E, Rosenthal, I (B47) 1985; 47
Evangelou, G, Krasagakis, K, Giannikaki, E, Kruger-Krasagakis, S, Tosca, A (B13) 2011; 27
Ramirez, H, Patel, SB, Pastar, I (B56) 2014; 3
Kunzler, B (B7) 2013; 13
Robledo, SM, Wozencraft, A, Valencia, AZ, Saravia, N (B26) 1994; 152
Saw, CL, Olivo, M, Soo, KC, Heng, PW (B21) 2006; 241
Nafee, N, Youssef, A, El-Gowelli, H, Asem, H, Kandil, S (B22) 2013; 454
Barbosa, F, Sangiorgi, BB, Galdino, SL, Barral-Netto, M, Pitta, IR, Pinheiro, AL (B15) 2012; 44
Perez-Victoria, FJ, Sanchez-Canete, MP, Seifert, K, Croft, SL, Sundar, S, Castanys, S, Gamarro, F (B9) 2006; 9
Blažević, T, Schwaiberger, AV, Schreiner, CE, Schachner, D, Schaible, AM, Grojer, CS, Atanasov, AG, Werz, O, Dirsch, VM, Heiss, EH (B52) 2013; 288
Davids, LM, Kleemann, B, Kacerovská, D, Pizinger, K, Kidson, SH (B39) 2008; 91
Mateus, JE, Valdivieso, W, Hernández, IP, Martínez, F, Páez, E, Escobar, P (B18) 2014; 34
Robledo, SM, Osorio, E, Muñoz, DL, Jaramillo, LM, Restrepo, A, Arango, G, Vélez, ID (B28) 2005; 49
Escobar, P, Hernández, IP, Rueda, CM, Martínez, F, Páez, E (B17) 2006; 26
Kawczyk-Krupka Czuba, Z, Szliszka, E, Król, W, Sieroń, A (B42) 2011; 26
Singh, S, Sarma, S, Katiyar, SP, Das, M, Bhardwaj, R, Sundar, D, Dubey, VK (B25) 2015; 59
Schäfer, M, Werner, S (B51) 2008; 58
Killick-Kendrick, R (B5) 1990; 4
Carrillo, LM, Montoya, EA, Arbeláez, N, Cadena, H, Ramírez, J, Robledo, SM (B33) 2014; 17
Enk, CD, Levi, A (B38) 2012; 28
(B41) 2015
Finney, JD (B29) 1978
Falanga, V (B48) 2005; 366
Soneja, A, Drews, M, Malinski, T (B53) 2005; 57
Sundar, S, Chakravarty, J (B6) 2010; 7
Hejazi, SH, Hoseini, S, Javanmard, SH, Zarkesh, SH, Khamesipour, A (B55) 2012; 7
e_1_3_2_26_2
e_1_3_2_49_2
e_1_3_2_28_2
e_1_3_2_41_2
e_1_3_2_20_2
e_1_3_2_43_2
e_1_3_2_22_2
e_1_3_2_45_2
e_1_3_2_24_2
e_1_3_2_47_2
World Health Organization (e_1_3_2_4_2) 2010; 949
e_1_3_2_9_2
e_1_3_2_16_2
e_1_3_2_37_2
e_1_3_2_7_2
e_1_3_2_39_2
LifeMap Discovery (e_1_3_2_42_2) 2015
Hejazi SH (e_1_3_2_56_2) 2012; 7
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_52_2
e_1_3_2_5_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_58_2
e_1_3_2_3_2
e_1_3_2_14_2
Finney JD (e_1_3_2_30_2) 1978
e_1_3_2_50_2
Kunzler B (e_1_3_2_8_2) 2013; 13
Soneja A (e_1_3_2_54_2) 2005; 57
e_1_3_2_48_2
Escobar P (e_1_3_2_18_2) 2006; 26
e_1_3_2_29_2
OECD (e_1_3_2_35_2) 2004
e_1_3_2_40_2
Robledo SM (e_1_3_2_27_2) 1994; 152
e_1_3_2_21_2
e_1_3_2_23_2
e_1_3_2_44_2
e_1_3_2_25_2
e_1_3_2_46_2
Carrillo LM (e_1_3_2_34_2) 2014; 17
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_17_2
e_1_3_2_59_2
e_1_3_2_6_2
e_1_3_2_19_2
e_1_3_2_53_2
e_1_3_2_32_2
e_1_3_2_51_2
e_1_3_2_11_2
e_1_3_2_57_2
e_1_3_2_13_2
e_1_3_2_36_2
e_1_3_2_55_2
e_1_3_2_2_2
References_xml – volume: 16
  start-page: 651
  year: 2007
  end-page: 660
  ident: B12
  article-title: Parasiticidal effect of delta-aminolevulinic acid-based photodynamic therapy for cutaneous leishmaniasis is indirect and mediated through the killing of the host cells
  publication-title: Exp Dermatol
  doi: 10.1111/j.1600-0625.2007.00578.x
  contributor:
    fullname: Hasan, T
– year: 2004
  ident: B34
  article-title: OECD guideline for the testing of chemicals
  publication-title: Skin absorption: in vitro method ;OECD guideline 428 ;Organisation for Economic Co-operation and Development ;Paris, France
– volume: 158
  start-page: 360
  year: 2008
  end-page: 369
  ident: B45
  article-title: Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin
  publication-title: Br J Dermatol
  doi: 10.1111/j.1365-2133.2007.08329.x
  contributor:
    fullname: de Witte, PA
– volume: 122
  start-page: 134
  year: 2009
  end-page: 139
  ident: B30
  article-title: Leishmania (Viannia) panamensis: an in vitro assay using the expression of GFP for screening of antileishmanial drug
  publication-title: Exp Parasitol
  doi: 10.1016/j.exppara.2009.02.012
  contributor:
    fullname: Muskus, C
– volume: 140
  start-page: 223
  year: 2013
  end-page: 228
  ident: B37
  article-title: PDT panoramic view. Principle, photosensitizers, light sources and validated indications in dermatology
  publication-title: Ann Dermatol Venereol
  doi: 10.1016/S0151-9638(13)70138-8
  contributor:
    fullname: Basset-Seguin, N
– volume: 91
  start-page: 67
  year: 2008
  end-page: 76
  ident: B39
  article-title: Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells
  publication-title: J Photochem Photobiol A Chem
  doi: 10.1016/j.jphotobiol.2008.01.011
  contributor:
    fullname: Kidson, SH
– volume: 7
  start-page: 35671
  year: 2012
  end-page: 35683
  ident: B2
  article-title: Leishmaniasis worldwide and global estimates of its incidence
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0035671
  contributor:
    fullname: den Boer, M
– volume: 6
  start-page: 170
  year: 2009
  end-page: 188
  ident: B11
  article-title: Photodynamic therapy for localized infections—state of the art
  publication-title: Photodiagnosis Photodyn Ther
  doi: 10.1016/j.pdpdt.2009.10.008
  contributor:
    fullname: Hamblin, MR
– volume: 2
  start-page: 329
  year: 2007
  end-page: 333
  ident: B36
  article-title: In vitro scratch assay: a convenient and inexpensive method for analysis of a cell migration in vitro
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2007.30
  contributor:
    fullname: Guan, JL
– volume: 3
  start-page: 482
  year: 2014
  end-page: 491
  ident: B56
  article-title: The role of TGFβ signaling in wound epithelialization
  publication-title: Adv Wound Care (New Rochelle)
  doi: 10.1089/wound.2013.0466
  contributor:
    fullname: Pastar, I
– volume: 9
  start-page: 26
  year: 2006
  end-page: 39
  ident: B9
  article-title: Mechanisms of experimental resistance of Leishmania to miltefosine: implications for clinical use
  publication-title: Drug Resist Updat
  doi: 10.1016/j.drup.2006.04.001
  contributor:
    fullname: Gamarro, F
– volume: 76
  start-page: 1819
  year: 2013
  end-page: 1823
  ident: B23
  article-title: Biological evaluation of hyperforin and its hydrogenated analogue on bacterial growth and biofilm production
  publication-title: J Nat Prod
  doi: 10.1021/np400394c
  contributor:
    fullname: Corbo, F
– volume: 4
  start-page: 130
  year: 2007
  end-page: 139
  ident: B44
  article-title: Effect of vehicles and esterification on the penetration and distribution of hypericin in the skin of hairless mice
  publication-title: Photodiagnosis Photodyn Ther
  doi: 10.1016/j.pdpdt.2007.02.002
  contributor:
    fullname: de Witte, PA
– volume: 13
  start-page: 61
  year: 2005
  end-page: 67
  ident: B54
  article-title: Transforming growth factor-beta and its effect on reepithelialization of partial-thickness ear wounds in transgenic mice
  publication-title: Wound Repair Regen
  doi: 10.1111/j.1067-1927.2005.130108.x
  contributor:
    fullname: Ghahary, A
– volume: 4
  start-page: 1
  year: 1990
  end-page: 24
  ident: B5
  article-title: Phlebotomine vectors of the leishmaniases: a review
  publication-title: Med Vet Entomol
  doi: 10.1111/j.1365-2915.1990.tb00255.x
  contributor:
    fullname: Killick-Kendrick, R
– volume: 949
  start-page: 1
  year: 2010
  end-page: 186
  ident: B3
  article-title: Control of the leishmaniasis: report of a meeting of the WHO Expert Committee on the Control of Leishmaniases
  publication-title: World Health Organ Tech Rep Ser
– volume: 53
  start-page: 65
  year: 1991
  end-page: 72
  ident: B46
  article-title: Chlorin and porphyrin derivatives as potential photosensitizers in photodynamic therapy
  publication-title: Photochem Photobiol
  doi: 10.1111/j.1751-1097.1991.tb08468.x
  contributor:
    fullname: Dougherty, TJ
– volume: 103
  start-page: 33
  year: 2007
  end-page: 40
  ident: B8
  article-title: Comparison of miltefosine and meglumine antimoniate for the treatment of zoonotic cutaneous leishmaniasis (ZCL) by a randomized clinical trial in Iran
  publication-title: Acta Trop
  doi: 10.1016/j.actatropica.2007.05.005
  contributor:
    fullname: Nadim, A
– volume: 7
  start-page: 4267
  year: 2010
  end-page: 4277
  ident: B6
  article-title: Antimony toxicity
  publication-title: Int J Environ Res Public Health
  doi: 10.3390/ijerph7124267
  contributor:
    fullname: Chakravarty, J
– volume: 13
  start-page: 2189
  year: 2006
  end-page: 2204
  ident: B43
  article-title: Cellular mechanisms and prospective applications of hypericin in photodynamic therapy
  publication-title: Curr Med Chem
  doi: 10.2174/092986706777935267
  contributor:
    fullname: Plaetzer, K
– volume: 26
  start-page: 49
  year: 2006
  end-page: 56
  ident: B17
  article-title: Photodynamic activity of aluminium(III) and zinc(II) phthalocyanines in Leishmania promastigotes
  publication-title: Biomedica
  contributor:
    fullname: Páez, E
– volume: 241
  start-page: 23
  year: 2006
  end-page: 30
  ident: B21
  article-title: Delivery of hypericin for photodynamic applications
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2005.10.020
  contributor:
    fullname: Heng, PW
– volume: 5
  start-page: e9730
  year: 2010
  ident: B27
  article-title: Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0009730
  contributor:
    fullname: Salmon, M
– year: 1978
  ident: B29
  publication-title: Statistical method in biological assay ;Griffin ;London, United Kingdom.
  contributor:
    fullname: Finney, JD
– volume: 7
  start-page: 16
  year: 2012
  end-page: 23
  ident: B55
  article-title: Interleukin-10 and transforming growth factor-β in early and late lesions of patients with Leishmania major induced cutaneous leishmaniasis
  publication-title: Iran J Parasitol
  contributor:
    fullname: Khamesipour, A
– volume: 57
  start-page: 35
  year: 2014
  end-page: 42
  ident: B20
  article-title: Photodynamic fungicidal efficacy of hypericin and dimethyl methylene blue against azole-resistant Candida albicans strains
  publication-title: Mycoses
  doi: 10.1111/myc.12099
  contributor:
    fullname: Gilaberte, Y
– volume: 27
  start-page: 254
  year: 2011
  end-page: 256
  ident: B13
  article-title: Successful treatment of cutaneous leishmaniasis with intralesional aminolevulinic acid photodynamic therapy
  publication-title: Photodermatol Photoimmunol Photomed
  doi: 10.1111/j.1600-0781.2011.00610.x
  contributor:
    fullname: Tosca, A
– volume: 34
  start-page: 589
  year: 2014
  end-page: 597
  ident: B18
  article-title: Cell accumulation and antileishmanial effect of exogenous and endogenous protoporphyrin IX after photodynamic treatment
  publication-title: Biomedica
  doi: 10.1590/S0120-41572014000400012
  contributor:
    fullname: Escobar, P
– volume: 44
  start-page: 850
  year: 2012
  end-page: 855
  ident: B15
  article-title: Photodynamic antimicrobial chemotherapy (PACT) using phenothiazine derivatives as photosensitizers against Leishmania braziliensis
  publication-title: Lasers Surg Med
  doi: 10.1002/lsm.22099
  contributor:
    fullname: Pinheiro, AL
– volume: 26
  start-page: 275
  year: 2011
  end-page: 280
  ident: B42
  article-title: The role of photosensitized macrophages in photodynamic therapy
  publication-title: Oncol Rep
  doi: 10.3892/or.2011.1262
  contributor:
    fullname: Sieroń, A
– volume: 62
  start-page: e3533
  year: 2012
  ident: B32
  article-title: Cutaneous leishmaniasis in the dorsal skin of hamsters: a useful model for the screening of anti-leishmanial drugs
  publication-title: J Vis Exp
  doi: 10.3791/3533
  contributor:
    fullname: Vélez, ID
– volume: 454
  start-page: 249
  year: 2013
  end-page: 258
  ident: B22
  article-title: Antibiotic-free nanotherapeutics: hypericin nanoparticles thereof for improved in vitro and in vivo antimicrobial photodynamic therapy and wound healing
  publication-title: Int J Pharm
  doi: 10.1016/j.ijpharm.2013.06.067
  contributor:
    fullname: Kandil, S
– volume: 57
  start-page: 108
  year: 2005
  end-page: 119
  ident: B53
  article-title: Role of nitric oxide, nitroxidative and oxidative stress in wound healing
  publication-title: Pharmacol Rep
  contributor:
    fullname: Malinski, T
– volume: 179
  start-page: 2014
  year: 2008
  end-page: 2019
  ident: B40
  article-title: Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of E-cadherin
  publication-title: J Urol
  doi: 10.1016/j.juro.2007.12.038
  contributor:
    fullname: de Witte, PA
– volume: 55
  start-page: 4755
  year: 2011
  end-page: 4764
  ident: B10
  article-title: In vitro and in vivo studies of the utility of dimethyl and diethyl carbaporphyrin ketals in treatment of cutaneous leishmaniasis
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.00671-11
  contributor:
    fullname: Robledo, SM
– volume: 74
  start-page: 451
  year: 2012
  end-page: 455
  ident: B58
  article-title: Role of epidermal growth factor in healing of diabetic foot ulcers
  publication-title: Indian J Surg
  doi: 10.1007/s12262-012-0447-2
  contributor:
    fullname: Singla, M
– volume: 288
  start-page: 35592
  year: 2013
  end-page: 35603
  ident: B52
  article-title: 12/15-Lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.489013
  contributor:
    fullname: Heiss, EH
– volume: 17
  start-page: 341
  year: 2014
  end-page: 350
  ident: B33
  article-title: Migration of Leishmania (Viannia) panamensis and its persistence in healthy skin of hamster
  publication-title: Rev UDCA Actualidad Divulgacion Científica
  contributor:
    fullname: Robledo, SM
– volume: 7
  start-page: e41105
  year: 2012
  ident: B35
  article-title: Amniotic mesenchymal stem cells enhance wound healing in diabetic NOD/SCID mice through high angiogenic andengraftment capabilities
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0041105
  contributor:
    fullname: Kim, MH
– volume: 12
  start-page: 419
  year: 2004
  end-page: 429
  ident: B50
  article-title: Comparison of oxidative stress biomarker profiles between acute and chronic wound environments
  publication-title: Wound Repair Regen
  doi: 10.1111/j.1067-1927.2004.12406.x
  contributor:
    fullname: Thomas, DW
– volume: 13
  start-page: 40
  year: 2013
  end-page: 55
  ident: B7
  article-title: Cutaneous leishmaniasis: the efficacy of non-antimony treatment in the austere environment
  publication-title: Using cryotherapy, thermotherapy, and photodynamic therapy as an alternative method of treatment. J Spec Oper Med
  contributor:
    fullname: Kunzler, B
– volume: 276
  start-page: 75
  year: 1997
  end-page: 81
  ident: B49
  article-title: Wound healing—aiming for perfect skin regeneration
  publication-title: Science
  doi: 10.1126/science.276.5309.75
  contributor:
    fullname: Martin, P
– volume: 152
  start-page: 1265
  year: 1994
  end-page: 1276
  ident: B26
  article-title: Human monocyte infection by Leishmania (Viannia) panamensis; role of complement receptors and correlation of susceptibility in vitro with clinical phenotype
  publication-title: J Immunol
  contributor:
    fullname: Saravia, N
– volume: 139
  start-page: 432
  year: 2003
  end-page: 434
  ident: B14
  article-title: Treatment of cutaneous leishmaniasis with photodynamic therapy
  publication-title: Arch Dermatol
  doi: 10.1001/archderm.139.4.432
  contributor:
    fullname: Ruzicka, T
– volume: 59
  start-page: 15
  year: 2015
  end-page: 24
  ident: B25
  article-title: Probing the molecular mechanism of hypericin-induced parasite death provides insight in the role of spermidine beyond redox metabolism in Leishmania donovani. Antimicrob Agents Chemother
  doi: 10.1128/AAC.04169-14
  contributor:
    fullname: Dubey, VK
– volume: 128
  start-page: 353
  year: 2011 Photodynamic therapy for American cutaneous leishmaniasis: the efficacy of methylene blue in hamsters experimentally infected with Leishmania (Leishmania) amazonensis. Exp Parasitol
  end-page: 356
  ident: B16
  doi: 10.1016/j.exppara.2011.04.009
  contributor:
    fullname: Silveira, TG
– volume: 111
  start-page: 13379
  year: 2014
  end-page: 13384
  ident: B57
  article-title: Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1324235111
  contributor:
    fullname: Ornitz, DM
– volume: 49
  start-page: 1652
  year: 2005
  end-page: 1655
  ident: B28
  article-title: In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.49.4.1652-1655.2005
  contributor:
    fullname: Vélez, ID
– year: 2015
  ident: B41
  publication-title: Embryonic development and stem cell compendium ;http://discovery.lifemapsc.com ;LifeMap Sciences, Inc. ;Marshfield, MA
– volume: 58
  start-page: 165
  year: 2008
  end-page: 171
  ident: B51
  article-title: Oxidative stress in normal and impaired wound repair
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2008.06.004
  contributor:
    fullname: Werner, S
– volume: 122
  start-page: 36
  year: 2012
  end-page: 45
  ident: B31
  article-title: Improvement of the green fluorescent protein reporter system in Leishmania spp. for the in vitro and in vivo screening of antileishmanial drugs
  publication-title: Acta Trop
  doi: 10.1016/j.actatropica.2011.11.015
  contributor:
    fullname: Robledo, SM
– volume: 28
  start-page: 332
  year: 2012
  end-page: 334
  ident: B38
  article-title: Low-irradiance red LED traffic lamps as light source in PDT for actinic keratoses
  publication-title: Photodermatol Photoimmunol Photomed
  doi: 10.1111/j.1600-0781.2012.00694.x
  contributor:
    fullname: Levi, A
– volume: 20
  start-page: 36
  year: 2014
  end-page: 46
  ident: B24
  article-title: Comparison of efficacy of topical phenytoin with hypericin in second-degree burn wound healing: an experimental study in rats
  publication-title: Med Sci Monit Basic Res
  doi: 10.12659/MSMBR.890337
  contributor:
    fullname: Karabay, G
– volume: 34
  start-page: 551
  year: 2012
  end-page: 561
  ident: B1
  article-title: Tissue damage and immunity in cutaneous leishmaniasis
  publication-title: Parasite Immunol
  doi: 10.1111/pim.12007
  contributor:
    fullname: Eidsmo, L
– volume: 10
  start-page: 150
  year: 2013
  end-page: 155
  ident: B19
  article-title: Photodynamic effect of hypericin on the microorganisms and primary human fibroblasts
  publication-title: Photodiagnosis Photodyn Ther
  doi: 10.1016/j.pdpdt.2012.11.007
  contributor:
    fullname: Djavid, GE
– volume: 366
  start-page: 1736
  year: 2005
  end-page: 1743
  ident: B48
  article-title: Wound healing and its impairment in the diabetic foot
  publication-title: Lancet
  doi: 10.1016/S0140-6736(05)67700-8
  contributor:
    fullname: Falanga, V
– volume: 86
  start-page: 497
  year: 2011
  end-page: 506
  ident: B4
  article-title: Advances in the treatment of cutaneous leishmaniasis in the new world in the last ten years: a systematic literature review
  publication-title: An Bras Dermatol
  doi: 10.1590/S0365-05962011000300012
  contributor:
    fullname: Santos, JB
– volume: 47
  start-page: 145
  year: 1985
  end-page: 147
  ident: B47
  article-title: The phthalocyanines: a new class of mammalian cells photosensitizers with a potential for cancer phototherapy
  publication-title: Int J Radiat Biol
  doi: 10.1080/09553008514550211
  contributor:
    fullname: Rosenthal, I
– ident: e_1_3_2_28_2
  doi: 10.1371/journal.pone.0009730
– ident: e_1_3_2_59_2
  doi: 10.1007/s12262-012-0447-2
– ident: e_1_3_2_47_2
  doi: 10.1111/j.1751-1097.1991.tb08468.x
– ident: e_1_3_2_2_2
  doi: 10.1111/pim.12007
– ident: e_1_3_2_22_2
  doi: 10.1016/j.canlet.2005.10.020
– ident: e_1_3_2_14_2
  doi: 10.1111/j.1600-0781.2011.00610.x
– ident: e_1_3_2_57_2
  doi: 10.1089/wound.2013.0466
– ident: e_1_3_2_7_2
  doi: 10.3390/ijerph7124267
– ident: e_1_3_2_51_2
  doi: 10.1111/j.1067-1927.2004.12406.x
– ident: e_1_3_2_5_2
  doi: 10.1590/S0365-05962011000300012
– ident: e_1_3_2_37_2
  doi: 10.1038/nprot.2007.30
– ident: e_1_3_2_33_2
  doi: 10.3791/3533
– ident: e_1_3_2_41_2
  doi: 10.1016/j.juro.2007.12.038
– ident: e_1_3_2_46_2
  doi: 10.1111/j.1365-2133.2007.08329.x
– ident: e_1_3_2_52_2
  doi: 10.1016/j.phrs.2008.06.004
– ident: e_1_3_2_11_2
  doi: 10.1128/AAC.00671-11
– ident: e_1_3_2_43_2
  doi: 10.3892/or.2011.1262
– ident: e_1_3_2_10_2
  doi: 10.1016/j.drup.2006.04.001
– ident: e_1_3_2_36_2
  doi: 10.1371/journal.pone.0041105
– volume: 13
  start-page: 40
  year: 2013
  ident: e_1_3_2_8_2
  article-title: Cutaneous leishmaniasis: the efficacy of non-antimony treatment in the austere environment
  publication-title: Using cryotherapy, thermotherapy, and photodynamic therapy as an alternative method of treatment. J Spec Oper Med
  contributor:
    fullname: Kunzler B
– ident: e_1_3_2_38_2
  doi: 10.1016/S0151-9638(13)70138-8
– ident: e_1_3_2_19_2
  doi: 10.1590/S0120-41572014000400012
– ident: e_1_3_2_3_2
  doi: 10.1371/journal.pone.0035671
– ident: e_1_3_2_32_2
  doi: 10.1016/j.actatropica.2011.11.015
– ident: e_1_3_2_12_2
  doi: 10.1016/j.pdpdt.2009.10.008
– ident: e_1_3_2_6_2
  doi: 10.1111/j.1365-2915.1990.tb00255.x
– ident: e_1_3_2_9_2
  doi: 10.1016/j.actatropica.2007.05.005
– ident: e_1_3_2_21_2
  doi: 10.1111/myc.12099
– volume-title: Skin absorption: in vitro method
  year: 2004
  ident: e_1_3_2_35_2
  contributor:
    fullname: OECD
– ident: e_1_3_2_44_2
  doi: 10.2174/092986706777935267
– ident: e_1_3_2_29_2
  doi: 10.1128/AAC.49.4.1652-1655.2005
– ident: e_1_3_2_39_2
  doi: 10.1111/j.1600-0781.2012.00694.x
– ident: e_1_3_2_58_2
  doi: 10.1073/pnas.1324235111
– ident: e_1_3_2_20_2
  doi: 10.1016/j.pdpdt.2012.11.007
– ident: e_1_3_2_16_2
  doi: 10.1002/lsm.22099
– ident: e_1_3_2_24_2
  doi: 10.1021/np400394c
– volume: 57
  start-page: 108
  year: 2005
  ident: e_1_3_2_54_2
  article-title: Role of nitric oxide, nitroxidative and oxidative stress in wound healing
  publication-title: Pharmacol Rep
  contributor:
    fullname: Soneja A
– ident: e_1_3_2_23_2
  doi: 10.1016/j.ijpharm.2013.06.067
– volume-title: Statistical method in biological assay
  year: 1978
  ident: e_1_3_2_30_2
  contributor:
    fullname: Finney JD
– volume: 949
  start-page: 1
  year: 2010
  ident: e_1_3_2_4_2
  article-title: Control of the leishmaniasis: report of a meeting of the WHO Expert Committee on the Control of Leishmaniases
  publication-title: World Health Organ Tech Rep Ser
  contributor:
    fullname: World Health Organization
– ident: e_1_3_2_25_2
  doi: 10.12659/MSMBR.890337
– ident: e_1_3_2_45_2
  doi: 10.1016/j.pdpdt.2007.02.002
– volume: 152
  start-page: 1265
  year: 1994
  ident: e_1_3_2_27_2
  article-title: Human monocyte infection by Leishmania (Viannia) panamensis; role of complement receptors and correlation of susceptibility in vitro with clinical phenotype
  publication-title: J Immunol
  doi: 10.4049/jimmunol.152.3.1265
  contributor:
    fullname: Robledo SM
– volume: 7
  start-page: 16
  year: 2012
  ident: e_1_3_2_56_2
  article-title: Interleukin-10 and transforming growth factor-β in early and late lesions of patients with Leishmania major induced cutaneous leishmaniasis
  publication-title: Iran J Parasitol
  contributor:
    fullname: Hejazi SH
– ident: e_1_3_2_55_2
  doi: 10.1111/j.1067-1927.2005.130108.x
– ident: e_1_3_2_40_2
  doi: 10.1016/j.jphotobiol.2008.01.011
– volume: 26
  start-page: 49
  year: 2006
  ident: e_1_3_2_18_2
  article-title: Photodynamic activity of aluminium(III) and zinc(II) phthalocyanines in Leishmania promastigotes
  publication-title: Biomedica
  contributor:
    fullname: Escobar P
– ident: e_1_3_2_13_2
  doi: 10.1111/j.1600-0625.2007.00578.x
– ident: e_1_3_2_15_2
  doi: 10.1001/archderm.139.4.432
– ident: e_1_3_2_31_2
  doi: 10.1016/j.exppara.2009.02.012
– ident: e_1_3_2_48_2
  doi: 10.1080/09553008514550211
– ident: e_1_3_2_17_2
  doi: 10.1016/j.exppara.2011.04.009
– ident: e_1_3_2_26_2
  doi: 10.1128/AAC.04169-14
– volume-title: Embryonic development and stem cell compendium
  year: 2015
  ident: e_1_3_2_42_2
  contributor:
    fullname: LifeMap Discovery
– volume: 17
  start-page: 341
  year: 2014
  ident: e_1_3_2_34_2
  article-title: Migration of Leishmania (Viannia) panamensis and its persistence in healthy skin of hamster
  publication-title: Rev UDCA Actualidad Divulgacion Científica
  contributor:
    fullname: Carrillo LM
– ident: e_1_3_2_50_2
  doi: 10.1126/science.276.5309.75
– ident: e_1_3_2_53_2
  doi: 10.1074/jbc.M113.489013
– ident: e_1_3_2_49_2
  doi: 10.1016/S0140-6736(05)67700-8
SSID ssj0006590
Score 2.408622
Snippet An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum, is...
ABSTRACT An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum ,...
An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum , is...
SourceID pubmedcentral
proquest
crossref
asm2
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 5804
SubjectTerms Animals
Anthracenes
Cell Line
Cricetinae
Experimental Therapeutics
Humans
Leishmania - drug effects
Leishmania - pathogenicity
Leishmaniasis, Cutaneous
Leishmaniasis, Cutaneous - drug therapy
Leishmaniasis, Cutaneous - therapy
Perylene
Perylene - analogs & derivatives
Perylene - therapeutic use
Photochemotherapy
Photochemotherapy - methods
Photosensitizing Agents
Photosensitizing Agents - therapeutic use
U937 Cells
Wound Healing - drug effects
Title Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies
URI https://www.ncbi.nlm.nih.gov/pubmed/26169411
https://journals.asm.org/doi/10.1128/AAC.00545-15
https://search.proquest.com/docview/1704347672
https://pubmed.ncbi.nlm.nih.gov/PMC4538502
Volume 59
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfWSSBe0CgfK4PpQLCnpU0c20keS0VVPjoVqUN7i2zHUSPRZFpSpPwX_Mmc87GtIF54iZTEsazcne9n-3d3hLxTlCmWaOEIhfCNMWWcKPEjJ1WaMo1X19j9juWFWFyyz1f86oDwPhamIe1rlY3zH9txnm0abuX1Vk96nthktZwxtFLu0smADALf75fo3fQreLuxgr7UYaHLerY7DSfT6WxsMQp3PFuxBhcPNozTBs_Lckv3PdNfcPNP1uQ9NzQ_Io87_AjTdpxPyIHJh-RBW1GyHpKHy-6sfEjOVm1W6voc1ndBVuU5nMHqLl91_ZT8ukccgiIFCRcFPoA5wtmuuBfY7VpY1DYtMvYO6wLWFm3CbIfg0hS7Er6arNzYZBqyzEr4gM4xAfxwtSmqImnL3nfjqAF7-JTD96y6KUDmSXvzs4CO1PiMXM4_rmcLpyvU4Eg_dCtHR27qJSqUIZUIIU0qogCRoQmMxTcycJn2cR6VLNJUKE_QNFQRkyYSknOaCv85OcyL3BwTQPihtWIhT2xG4dBIFnAdpS4zfhK4io3IWyuruLO0Mm4WMTSMUbZxI9vY4yPyvpdkfN0m7fhHuze9mGO0KntU0v6z2MMx-ywQAR2RF63Yb3vq1WZEgj2FuG1gM3bvv0FFbjJ3d4r78r-_PCGPELHxluT2ihxWNzvzGlFRpU7J4Mu38LSxhd9GAwzX
link.rule.ids 230,315,733,786,790,891,27955,27956,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwGLXGEJcXLmVAuX4g2NPSJo6dy2OpqDpoqz50094i23HUCJpMS4oUfgU_mc-5bOsQD_ASJbFj2dGxfWwfHxPyQVImWaw8y5NI3xiT2gpjN7QSqShTeLW1me-YL7zpCftyxs_2CO_2wtSifSXTQfZ9M8jSda2tPN-oYacTGy7nY4a1lNt0eIvcxjvKu0F62wB7vJlawd7UYoHNOr07DYaj0XhgWAq3HHNmDQ4fzEZOs31eFBu62zf9QThv6iavdUSTh-S0K0KjP_k22JZyoH7ecHf85zI-Ig9aagqjJvgx2dNZj9xpDquseuTuvF2G75HDZWN4XR3B6mr_VnEEh7C8ssKunpBf1zRJkCcgYJHjC5ggU27PDQMzEwzTyjguY-qwymFliCyMt8hbdb4tYKbTYm18OkSRFvAJ-90Y8MPlOi_zuMrEJlVtPirAFI4zOE3LixxEFjcPP3Jo9ZIH5GTyeTWeWu0ZEJZwA7u0VGgnTiwDEVCB7FQnXugj6dS-NtRJ-DZTLjbRgoWKetLxaBLIkAkdeoJzmnjuU7Kf5Zl-TgCZjVKSBTw2ZsWBFsznKkxspt3YtyXrk_cGBFFbiYuoHh_RIELQRDVoIof3yccOItF54wfyl3jvOvxEWGHNKkzzzyIH8-wy3_Npnzxr8HSZUofHPvF3kHYZwZiB74YgfmpT8BYvL_77y7fk3nQ1n0Wz48XXl-Q-EkPeaOlekf3yYqtfI_kq5Zu6qv0GGlkt0w
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwGLVgiIkXLuWycv1AsKflUse5PZZC1cFa9aFD014i23HUiDWplhQp_Ap-Mp9z2dohXvYSKYljOdH54mP7-HyEfBSUCRZLz_AE0jfGhDLC2AmNREjKJB5tpec7pjNvcsq-nblnW6m-atG-FKmZXazMLF3W2sr1SlqdTsyaT0cMo9S1qbWOE-suuYdn1O8G6u1P2HOb6RXsUQ0W2KzTvNPAGg5HpmYqrjHQeWtwCKE3c-ot9LxY0d3-6R_SeVM7udUZjR-R8-41Gg3KT3NTClP-vuHweKv3fEwethQVhk2RJ-SOynrkfpO0suqR_Wm7HN8jh_PG-Lo6gsX1Pq7iCA5hfm2JXT0lf7a0SZAnwGGW4wUYI2Nu84eBnhGGSaWdl7F2WOSw0IQWRhvkryrfFHCi0mKp_Tp4kRbwGfvfGPDB-TIv87jK-CqVbTsqwBqOM_iRlpc58CxuTn7l0Oomn5HT8dfFaGK0uSAM7gR2acjQTgaxCHhAObJUlXihj-RT-UpTKO7bTDr4q-YslNQTA48mgQgZV6HHXZcmnvOc7GV5pg4IIMORUrDAjbVpcaA4810ZJjZTTuzbgvXJBw2EqA3mIqrHSTSIEDhRDZxo4PbJpw4m0brxBflPufcdhiIMXL0a03yzaIBtdpjv-bRPXjSYuqqpw2Sf-DtouyqgTcF37yCGanPwFjMvb_3kO7I__zKOTo5n31-RB8gP3UZS95rslZcb9QY5WCne1tH2F4qqMFM
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Development+of+a+Novel+Formulation+with+Hypericin+To+Treat+Cutaneous+Leishmaniasis+Based+on+Photodynamic+Therapy+in+In+Vitro+and+In+Vivo+Studies&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.au=Montoya%2C+Andr%C3%A9s&rft.au=Daza%2C+Alejandro&rft.au=Mu%C3%B1oz%2C+Diana&rft.au=R%C3%ADos%2C+Karina&rft.date=2015-09-01&rft.issn=0066-4804&rft.eissn=1098-6596&rft.volume=59&rft.issue=9&rft.spage=5804&rft.epage=5813&rft_id=info:doi/10.1128%2FAAC.00545-15&rft.externalDBID=n%2Fa&rft.externalDocID=10_1128_AAC_00545_15
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0066-4804&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0066-4804&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0066-4804&client=summon