Using Absorption Simulation and Gastric pH Modulated Dog Model for Formulation Development To Overcome Achlorhydria Effect

• Published in: Molecular pharmaceutics Vol. 8; no. 6; pp. 2216 - 2223
• Main Authors: Mitra, Amitava, Kesisoglou, Filippos, Beauchamp, Martyn, Zhu, Wei, Chiti, Fabio, Wu, Yunhui
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 05.12.2011
• Subjects: Achlorhydria - chemically induced; Animals; Chemistry, Pharmaceutical; Dogs; Famotidine - blood; Famotidine - pharmacokinetics; Humans; Hydrogen-Ion Concentration; Intestinal Absorption - drug effects; Male; Models, Biological; Pentagastrin - blood; Pentagastrin - pharmacokinetics; Solubility; dog study; modeling; famotidine; simulation; dissolution; pharmacokinetics; achlorhydria

Impaired absorption of weakly basic drugs in patients with reduced gastric acidity can lead to loss of efficacy of the therapeutic agent. Hence, a robust formulation which can provide adequate exposure in achlorhydric patients is imperative to achieve the desired efficacy. In this report, formulatio...