Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells

• Published in: ACS nano Vol. 5; no. 5; pp. 3679 - 3692
• Main Authors: Wang, Feng, Wang, Yu-Cai, Dou, Shuang, Xiong, Meng-Hua, Sun, Tian-Meng, Wang, Jun
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.05.2011
• Subjects: Antibiotics, Antineoplastic - administration & dosage; Antibiotics, Antineoplastic - chemistry; Apoptosis - drug effects; Cell Line, Tumor; Doxorubicin - administration & dosage; Doxorubicin - chemistry; Drug Resistance, Multiple; Gold - chemistry; Humans; Nanocapsules - chemistry; Nanocapsules - ultrastructure; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - pathology; multidrug resistance; drug delivery; doxorubicin; nanosurface energy transfer; gold nanoparticles; intracellular drug release

Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. Through the development of a drug delivery system that tethers doxorubicin onto the surface of gold nanoparticles with a poly(ethylene glycol) spacer via an acid-labile linkage (DOX-Hyd@AuNPs), we have demonstrat...