DNA Damage Induced by Methylated Trivalent Arsenicals Is Mediated by Reactive Oxygen Species

• Published in: Chemical research in toxicology Vol. 15; no. 12; pp. 1627 - 1634
• Main Authors: Nesnow, Stephen, Roop, Barbara C, Lambert, Guy, Kadiiska, Maria, Mason, Ronald P, Cullen, William R, Mass, Marc J
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.12.2002
• Subjects: Arsenic - toxicity; Bacteriophage phi X 174 - chemistry; Bacteriophage phi X 174 - drug effects; Cacodylic Acid - analogs & derivatives; Cacodylic Acid - chemistry; Cacodylic Acid - metabolism; Cacodylic Acid - toxicity; Cyclic N-Oxides - chemistry; Cyclic N-Oxides - pharmacology; DNA Damage; DNA Methylation - drug effects; DNA, Superhelical - drug effects; Electron Spin Resonance Spectroscopy; Free Radical Scavengers - pharmacology; Humans; In Situ Nick-End Labeling - methods; methylated trivalent arsenicals; Organometallic Compounds - chemistry; Organometallic Compounds - metabolism; Organometallic Compounds - toxicity; oxygen radicals; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - chemistry; Reactive Oxygen Species - metabolism; Reactive Oxygen Species - toxicity; Spectrometry, Mass, Electrospray Ionization; Time Factors

Arsenic is a human carcinogen; however, the mechanisms of arsenic's induction of carcinogenic effects have not been identified clearly. We have shown previously that monomethylarsonous acid (MMAIII) and dimethylarsinous acid (DMAIII) are genotoxic and can damage supercoiled φX174 DNA and the DN...