Amino Acid/Spermine Conjugates: Polyamine Amides as Potent Spermidine Uptake Inhibitors
In this paper we describe the synthesis and characterization of a series of simple spermine/amino acid conjugates, some of which potently inhibit the uptake of spermidine into MDA-MB-231 breast cancer cells. The presence of an amide in the functionalized polyamine appeared to add to the affinity for...
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Published in | Journal of medicinal chemistry Vol. 44; no. 22; pp. 3632 - 3644 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
25.10.2001
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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