Efficient Synthesis of Enantiopure Pyrrolizidinone Amino Acid
Enantiopure (3S,5R,8S)-3-[N-(Boc)amino]-1-azabicyclo[3.3.0]octan-2-one 8-carboxylic acid (1) was synthesized in nine steps and 16% overall yield from aspartate β-aldehyde 7. Carbene-catalyzed acyloin condensation of 7, followed by acetylation and samarium iodide reduction, gave linear precursor (2S,...
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Published in | Journal of organic chemistry Vol. 68; no. 18; pp. 6988 - 6996 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
05.09.2003
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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