A Microchip Electrophoresis Device with Integrated Electrochemical Detection:  A Direct Comparison of Constant Potential Amperometry and Sinusoidal Voltammetry

• Published in: Analytical chemistry (Washington) Vol. 75; no. 14; pp. 3301 - 3307
• Main Authors: Hebert, Nicole E, Kuhr, Werner G, Brazill, Sara A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 15.07.2003
• Subjects: Analytical chemistry; Chemistry; Chromatographic methods and physical methods associated with chromatography; Electrochemical methods; Electrochemistry - instrumentation; Electrophoresis - instrumentation; Exact sciences and technology; Indicators and Reagents; Microcomputers; Nanotechnology; Other chromatographic methods; Dimethylsiloxane polymer; Gold; Isoprenaline; Dopamine; Electrochemical method; Glass; Voltammetry; Sensitivity; Detection limit; Amperometry; Neurotransmitter; Electrophoresis; Integrated system; Dopa; Comparative study

A microchip electrophoresis system with integrated electrochemical detection is described in this work. The hybrid device utilizes poly(dimethylsiloxane) as the electrophoresis channel substrate and a planar gold electrode lithographically fabricated onto a glass slide for electrochemical detection....