Synthesis of (−)-Homogalanthamine from Naltrexone
Acetylcholinesterase inhibitor (−)-homogalanthamine 3 was synthesized from μ opioid antagonist naltrexone (2) in 16% total yield. The synthesis features Grob fragmentation as a key reaction, which was especially accelerated in the presence of 15-crown-5.
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Published in | Journal of organic chemistry Vol. 76; no. 7; pp. 2257 - 2260 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
01.04.2011
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | Acetylcholinesterase inhibitor (−)-homogalanthamine 3 was synthesized from μ opioid antagonist naltrexone (2) in 16% total yield. The synthesis features Grob fragmentation as a key reaction, which was especially accelerated in the presence of 15-crown-5. |
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ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/jo1022487 |