Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women: A Randomized Clinical Trial

• Published in: JAMA : the journal of the American Medical Association Vol. 319; no. 17; pp. 1781 - 1789
• Main Authors: Huttner, Angela, Kowalczyk, Anna, Turjeman, Adi, Babich, Tanya, Brossier, Caroline, Eliakim-Raz, Noa, Kosiek, Katarzyna, Martinez de Tejada, Begoña, Roux, Xavier, Shiber, Shachaf, Theuretzbacher, Ursula, von Dach, Elodie, Yahav, Dafna, Leibovici, Leonard, Godycki-Cwirko, Maciek, Mouton, Johan W, Harbarth, Stephan
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 01.05.2018
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary - adverse effects; Anti-Infective Agents, Urinary - therapeutic use; Antibiotics; Clinical trials; Colonization; Cystitis; Diarrhea; Drug Administration Schedule; Drug Resistance, Bacterial; Esterase; Female; Fosfomycin; Fosfomycin - administration & dosage; Fosfomycin - adverse effects; Humans; Infections; Leukocytes; Middle Aged; Nausea; Nitrites; Nitrofurantoin; Nitrofurantoin - administration & dosage; Nitrofurantoin - adverse effects; Online First; Original Investigation; Patients; Therapy; Treatment Outcome; Urinary tract; Urinary tract infections; Urinary Tract Infections - drug therapy; Urine; Urine - microbiology; Women; Womens health; Young Adult

IMPORTANCE: The use of nitrofurantoin and fosfomycin has increased since guidelines began recommending them as first-line therapy for lower urinary tract infection (UTI). OBJECTIVE: To compare the clinical and microbiologic efficacy of nitrofurantoin and fosfomycin in women with uncomplicated cystit...